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Showing 1 to 20 of 145 for “"PLGA"”.

  1. Manipulating PLGA nanoparticle cellular uptake and trafficking

    Alsa'd, Alhareth Ahmad MohammadQueen's University Belfast2022

    … was to improve the efficacy of drug-loaded PLGA NPs through manipulating their cellular uptake and intracellular trafficking to a specific compartment inside the cell by modulating physicochemical properties i.e. size. Different sizes of Rhodamine-B conjugated PLGA NPs were synthesized and …

    qu-belfast Repository record

  2. Macromolecule Loading on PLGA Particles through Surface Adsorption

    Wang, Yiwei2019

    … nature, poly (d,l-lactic-co-glycolic acid) (PLGA) has been used extensively in formulating biological drugs into nano- and micro-sized particles. The development of PLGA biologic formulations, however, has been hampered by matrix acidification; the hydrolysis of the polymer generates …

    duquesne Repository record

  3. Elucidation of Drug Release Mechanisms in PLGA Microspheres

    Varde, Neelesh K.University of Illinois at Urbana-Champaign2015

    … elucidate mechanisms of drug release in PLGA microspheres. We showed the effect of microsphere size and presence of an antacid on the stability and release of plasmid DNA from PLGA microspheres. We demonstrated that the use of Mg(OH)2 as a stabilizing excipient affected the surface …

    uiuc Repository record

  4. Development of versatile drug delivery strategies using PLGA nanoparticles

    Fay, FrancoisQueen's University Belfast2010

    … a range of novel poly(lactic-co- glycolic acid) (PLGA) NP formulation strategies to deliver various drugs to targeted cells were examined.<br/><br/>A NP formulation for the intracellular delivery of plasmid DNA was developed, whereby the DNA was encapsulated within PLGA NP by combining salting out …

    qu-belfast Repository record

  5. Investigation of properties affecting controlled release of macromolecules from PLGA microspheres

    Stovall, Kalena D.University of Illinois at Urbana-Champaign2010

    Poly(lactide-co-glycolide), or PLGA, microspheres offer a widely-studied biodegradable option for controlled release of therapeutics. An array of fabrication methodologies have been developed to produce these microspheres with the capacity to encapsulate therapeutics of various types; and produce …

    uiuc Repository record

  6. Consistent Fabrication of Ultrasmall PLGA Nanoparticles and their Potential Biomedical Applications

    Lohneis, Taylor PaigeVirginia Tech2019

    … poly-(lactic-co-glycolic acid) nanoparticles (PLGA NPs) using a quick and easy nanoprecipitation method1, with some modifications, for general use in various biomedical areas. Nanoprecipitation of two solutions – PLGA dissolved in acetonitrile and aqueous poly(vinyl alcohol) (PVA) – at varying …

    vt Repository record

  7. Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections

    MANCA, MARIA LETIZIAUniversità degli Studi di Cagliari2007

    … during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) as well as stability during freeze-drying or/and nebulization (NEED%), were evaluated …

    cagliari Repository record

  8. Impact of end groups of PLGA on polymer properties and ocular implant performance

    Badawi, MariamUniversity of Strathclyde2018

    … at the intraocular target site. The FDA‑approved PLGA has been investigated for implantable ocular dosage forms. From a manufacturing stand point, the copolymer provides several merits. However, the risk of distortion on hydration causing endothelial contact, the biological fate of the polymeric …

    strathclyde Repository record

  9. PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells

    Tyagi, GarimaUniversity of Wolverhampton2020

    … acid) microparticle-encapsulate disulfiram (PLGA-DS) for local treatment of MM. This study aims to examine the anti-MM effect of PLGA-DS and elucidate its molecular mechanisms. Methodologies: In order to determine drug sensitivity, stemness, apoptosis, invasiveness and NFκB status, the …

    wlv Repository record

  10. Nanocomposites de óxido de titanio en membranas scaffold de plga en regeneración ósea guiada

    Castillo Dalí, Gabriel2013

    … membrana de ácido poliláctico-co-poliglicólico (PLGA) modificada a escala nanométrica con un pretratamiento físico de plasma de oxígeno (P-O2) (para favorecer su degradación en el tejido en formación) y la adición de óxido de titanio (TiO2), en relación a su capacidad para promover la …

    sevilla Repository record

  11. Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction

    Zhao, ZongminVirginia Tech2017

    … study, a lipid-poly(lactic-co-glycolic acid) (PLGA) nanoparticle-based next-generation nicotine vaccine has been developed to overcome the drawbacks of conjugate nicotine vaccines. Also, the influence of multiple factors, including nanoparticle size, hapten density, hapten localization, carrier …

    vt Repository record

  12. A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery

    Bedi, Sonia2016

    <p>Poly lactide‑co‑glycolide (PLGA) polymer has been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic …

    tenn-hsc Repository record

  13. Conjugation of Anti-HER2 Monoclonal Antibody onto a PLGA-PEG Nanoparticle Using CuAAC Click Chemistry

    Smith, EmilyUniversity of Cincinnati2012

    … of the antibody selected. In this work a PLGA-PEG nanoparticle was attached covalently to an anti-HER2 monoclonal antibody via click chemistry. The targeting ability of the conjugated system was analyzed via flow cytometry and fluorescent microscopy to determine its effectiveness and …

    ohiolink Repository record

  14. Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating

    Zhu, Xiaoxiang, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2014

    … particular a poly(lactic acid-co-glycolic acid) (PLGA) coating, for DES applications to improve the drug delivery and reduce adverse outcomes in patients. This dissertation aims to develop a mathematical model for describing the process of drug release from a biodegradable PLGA stent coating, and …

    mit Repository record

  15. Wundheilung athymischer Nacktmäuse nach Transplantation von kultivierten humanen Keratinozyten und Fibroblasten auf PLGA-Microsphären als Kokultur in Fibrinklebermatrix

    Dörrmann, Sascha

    … humanen Keratinozyten und Fibroblasten als PLGA-Microcarrier-Kokultur in einer Fibrinklebermatrix auf eine standardisierte dorsale Vollhautwunde der athymischen Nacktmaus. Makroskopische und Histologische Untersuchung der sich ausbildenden Neoepidermis und deren Basalmembranstrukturen im …

    freiburg-diss Repository record

  16. Modeling the sustained release of PLGA-based drug delivery systems with a physically-based model and pore space characterization

    Shi, XutaoUniversity of Delaware2022

    … an in vitro study of a drug-surrogate-embedded PLGA system. Reasonable agreement between model predictions and experimental drug release profiles was observed while discrepancies for certain formulations lead to a hypothesized correlation between first-phase rapid release and internal pore …

    udel Repository record

  17. INVESTIGATION OF LIGAND SIZE ON TARGETED PLGA NANOPARTICLES FOR HER2 BREAST CANCER: TRASTUZUMAB AND ITS ScFv ANTI-HER2 ANTIBODY

    Zagzoog, Ayat H 1990-University of Saskatchewan2018

    … breast cancer. Poly (D, L-lactide-co-glycolide) (PLGA) polymer, which is approved by FDA, was used to form nanoparticles (NPs) encapsulating docetaxel (DOC) as chemotherapy. HER2 antibody moieties, either whole IgG (TrAb) or single chain fragment variable (ScFv), were decorated on the PLGA NPs …

    sask Repository record

  18. Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications

    Sun, Yu, author, Li, Yan Vivian, advisor, Bailey, Travis, committee member, Wang, Zhijie, committee memberColorado State University. Libraries2019

    … In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound …

    colostate Repository record

  19. Modulation of cell morphology and function using synthetic biodegradable polymers

    Lu, LichunRice University1999

    … biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) has been fabricated into thin films for use as scaffolds for cell transplantation and guided tissue regeneration. We evaluated the ability of PLGA films to provide a suitable template for directing specific cell growth and tissue formation …

    rice Repository record

  20. Exploration of a doxorubicin-polymer conjugate in lipid-polymer hybrid nanoparticle drug delivery

    Lough, Emily Anne2017

    … doxorubicin-poly (lactic-co-glycolic) acid (Dox-PLGA) into a lipid-polymer hybrid nanoparticle (LPN). The primary difference in using a drug-polymer conjugate for NP drug delivery is the drug’s release kinetics. Dox-PLGA LPNs showed a more sustained and prolonged release profile over 28 days …

    bu Repository record

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