Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications

Wound treatment has always been a popular topic around the world. Since the emergence of nanotechnology, the development and design of novel wound dressing materials have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion evaporation method. Poly vinyl alcohol (PVA) was a surfactant that was an important factor in determining the most probable nanoparticle size and morphology. When the PVA concentrations were 9% and 12%, the nanoparticles demonstrated a spherical structure with a porous surface. The porous surface of a nanoparticle was promising for the purpose of releasing encapsulated antibiotics. Another important factor in determining the formation of nanoparticles was the PLGA concentration. Poly lactic-co-glycolic acid (PLGA) was the main material affecting PLGA nanoparticles' properties. PLGA nanoparticles would have various release profiles, morphology, and size distribution with different PLGA concentrations. The results suggested that different PLGA concentrations can endow PLGA nanoparticles with various properties which can lead to different applications of PLGA nanoparticles.

Name thesis:degree_name

Master of Science (M.S.)

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Advanced Materials Discovery

Grantor dc:publisher

Colorado State University. Libraries

Year dc:date.issued

2019

Authors dc:creator

• Sun, Yu, author
• Li, Yan Vivian, advisor
• Bailey, Travis, committee member
• Wang, Zhijie, committee member

• particle morphology and size
• release profile study
• PLGA nanoparticles
• drug delivery

Statement dc:rights

• Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.

Language dc:language.iso

eng, English

Identifier URI

https://doi.org/10.25675/3.018847

OAI identifier oai:identifier

oai:mountainscholar.org:10217/197434