{"id":{"repo_id":"colostate","oai_identifier":"oai:mountainscholar.org:10217/197434"},"canonical_url":"https://search.dev.ndltd.org/etd/colostate/oai:mountainscholar.org:10217/197434","repository":{"repo_id":"colostate","name":"Colorado State University","base_url":"https://api.mountainscholar.org/server/oai/request"},"display":{"title":"Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications","abstract":"Wound treatment has always been a popular topic around the world. Since the emergence of nanotechnology, the development and design of novel wound dressing materials have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion evaporation method. Poly vinyl alcohol (PVA) was a surfactant that was an important factor in determining the most probable nanoparticle size and morphology. When the PVA concentrations were 9% and 12%, the nanoparticles demonstrated a spherical structure with a porous surface. The porous surface of a nanoparticle was promising for the purpose of releasing encapsulated antibiotics. Another important factor in determining the formation of nanoparticles was the PLGA concentration. Poly lactic-co-glycolic acid (PLGA) was the main material affecting PLGA nanoparticles' properties. PLGA nanoparticles would have various release profiles, morphology, and size distribution with different PLGA concentrations. The results suggested that different PLGA concentrations can endow PLGA nanoparticles with various properties which can lead to different applications of PLGA nanoparticles.","abstract_html":"Wound treatment has always been a popular topic around the world. Since the emergence of nanotechnology, the development and design of novel wound dressing materials have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion evaporation method. Poly vinyl alcohol (PVA) was a surfactant that was an important factor in determining the most probable nanoparticle size and morphology. When the PVA concentrations were 9% and 12%, the nanoparticles demonstrated a spherical structure with a porous surface. The porous surface of a nanoparticle was promising for the purpose of releasing encapsulated antibiotics. Another important factor in determining the formation of nanoparticles was the PLGA concentration. Poly lactic-co-glycolic acid (PLGA) was the main material affecting PLGA nanoparticles' properties. PLGA nanoparticles would have various release profiles, morphology, and size distribution with different PLGA concentrations. The results suggested that different PLGA concentrations can endow PLGA nanoparticles with various properties which can lead to different applications of PLGA nanoparticles.","abstract_has_math":false,"creators":["Sun, Yu, author","Li, Yan Vivian, advisor","Bailey, Travis, committee member","Wang, Zhijie, committee member"],"institution":"Colorado State University. Libraries","degree_name":"Master of Science (M.S.)","degree_level":"Masters","degree_discipline":"Advanced Materials Discovery","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019","date_published":"2019","updated_at":"2026-07-27T19:13:18Z","subjects":["particle morphology and size","release profile study","PLGA nanoparticles","drug delivery"],"languages":["eng","English"],"rights":["Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://doi.org/10.25675/3.018847"],"render_values":[{"text":"https://doi.org/10.25675/3.018847","href":"https://doi.org/10.25675/3.018847","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10217/197434","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Sun, Yu, author","Li, Yan Vivian, advisor","Bailey, Travis, committee member","Wang, Zhijie, committee member"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2019-09-10T14:36:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2019-09-10T14:36:41Z"]},{"key":"dc:date.issued","label":"Date","values":["2019"]},{"key":"dc:publisher","label":"Institution","values":["Colorado State University. Libraries"]},{"key":"dc:type","label":"Dc Type","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Advanced Materials Discovery"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (M.S.)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Colorado State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["particle morphology and size","release profile study","PLGA nanoparticles","drug delivery"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["Sun_colostate_0053N_15665.pdf"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10217/197434","https://doi.org/10.25675/3.018847"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Wound treatment has always been a popular topic around the world. Since the emergence of nanotechnology, the development and design of novel wound dressing materials have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion evaporation method. Poly vinyl alcohol (PVA) was a surfactant that was an important factor in determining the most probable nanoparticle size and morphology. When the PVA concentrations were 9% and 12%, the nanoparticles demonstrated a spherical structure with a porous surface. The porous surface of a nanoparticle was promising for the purpose of releasing encapsulated antibiotics. Another important factor in determining the formation of nanoparticles was the PLGA concentration. Poly lactic-co-glycolic acid (PLGA) was the main material affecting PLGA nanoparticles' properties. PLGA nanoparticles would have various release profiles, morphology, and size distribution with different PLGA concentrations. The results suggested that different PLGA concentrations can endow PLGA nanoparticles with various properties which can lead to different applications of PLGA nanoparticles."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["born digital","masters theses"]},{"key":"dc:title","label":"Title","values":["Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications"]}]}],"canonical_facts":{"dc:creator":["Sun, Yu, author","Li, Yan Vivian, advisor","Bailey, Travis, committee member","Wang, Zhijie, committee member"],"dc:date.accessioned":["2019-09-10T14:36:41Z"],"dc:date.available":["2019-09-10T14:36:41Z"],"dc:date.issued":["2019"],"dc:description.abstract":["Wound treatment has always been a popular topic around the world. Since the emergence of nanotechnology, the development and design of novel wound dressing materials have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion evaporation method. Poly vinyl alcohol (PVA) was a surfactant that was an important factor in determining the most probable nanoparticle size and morphology. When the PVA concentrations were 9% and 12%, the nanoparticles demonstrated a spherical structure with a porous surface. The porous surface of a nanoparticle was promising for the purpose of releasing encapsulated antibiotics. Another important factor in determining the formation of nanoparticles was the PLGA concentration. Poly lactic-co-glycolic acid (PLGA) was the main material affecting PLGA nanoparticles' properties. PLGA nanoparticles would have various release profiles, morphology, and size distribution with different PLGA concentrations. The results suggested that different PLGA concentrations can endow PLGA nanoparticles with various properties which can lead to different applications of PLGA nanoparticles."],"dc:format.medium":["born digital","masters theses"],"dc:identifier":["Sun_colostate_0053N_15665.pdf"],"dc:identifier.uri":["https://hdl.handle.net/10217/197434","https://doi.org/10.25675/3.018847"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["Colorado State University. Libraries"],"dc:rights":["Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright."],"dc:subject":["particle morphology and size","release profile study","PLGA nanoparticles","drug delivery"],"dc:title":["Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications"],"dc:type":["Text"],"thesis:degree_discipline":["Advanced Materials Discovery"],"thesis:degree_level":["Masters"],"thesis:degree_name":["Master of Science (M.S.)"],"thesis:institution_name":["Colorado State University"]},"updated_at":"2026-07-27T19:13:18Z"}