{"id":{"repo_id":"umn","oai_identifier":"oai:conservancy.umn.edu:11299/190596"},"canonical_url":"https://search.dev.ndltd.org/etd/umn/oai:conservancy.umn.edu:11299/190596","repository":{"repo_id":"umn","name":"University of Minnesota","base_url":"https://conservancy.umn.edu/server/oai/request"},"display":{"title":"Biodegradable, Liquid-Filled, Spherical Capsules With Pre-Determined Burst Times","abstract":"A biodegradable poly(lactic acid-co-glycolic acid) (PLGA) capsule is presented in a spherical geometry, which exploits the principle of osmosis as an internal program to achieve a delayed-burst release of its load. The capsule burst lag-time is accurately predicted by modeling the rate of water uptake by the capsule core as a function of the capsule shell thickness, radius of the capsule, core osmotic pressure and the membrane tensile strength. Elastoplastic and failure characterization of PLGA was conducted as a function of hydration under uniaxial and biaxial stretch and by a novel “beach ball” inflation technique. The presence of small amounts of moisture leads to a decrease in yield stress and a decrease in elongation at break. The above presentation suggests reproducible preparation and evaluation of spherical rupturable osmotic capsules.","abstract_html":"A biodegradable poly(lactic acid-co-glycolic acid) (PLGA) capsule is presented in a spherical geometry, which exploits the principle of osmosis as an internal program to achieve a delayed-burst release of its load. The capsule burst lag-time is accurately predicted by modeling the rate of water uptake by the capsule core as a function of the capsule shell thickness, radius of the capsule, core osmotic pressure and the membrane tensile strength. Elastoplastic and failure characterization of PLGA was conducted as a function of hydration under uniaxial and biaxial stretch and by a novel “beach ball” inflation technique. The presence of small amounts of moisture leads to a decrease in yield stress and a decrease in elongation at break. The above presentation suggests reproducible preparation and evaluation of spherical rupturable osmotic capsules.","abstract_has_math":false,"creators":["Harish Jain, Krutika"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-06","date_published":"2017-06","updated_at":"2026-07-24T05:19:54Z","subjects":["Burst-type","Chronopharmaceutics","Elasto-plastic","Mathematical Model","Osmotic pumps","PLGA"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11299/190596","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Harish Jain, Krutika"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-10-09T16:54:55Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-10-09T16:54:55Z"]},{"key":"dc:date.issued","label":"Date","values":["2017-06"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Burst-type","Chronopharmaceutics","Elasto-plastic","Mathematical Model","Osmotic pumps","PLGA"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11299/190596"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["University of Minnesota M.S. thesis. June 2017. Major: Pharmaceutics. Advisor: Ronald Siegel. 1 computer file (PDF); ix, 121 pages."]},{"key":"dc:description.abstract","label":"Abstract","values":["A biodegradable poly(lactic acid-co-glycolic acid) (PLGA) capsule is presented in a spherical geometry, which exploits the principle of osmosis as an internal program to achieve a delayed-burst release of its load. The capsule burst lag-time is accurately predicted by modeling the rate of water uptake by the capsule core as a function of the capsule shell thickness, radius of the capsule, core osmotic pressure and the membrane tensile strength. Elastoplastic and failure characterization of PLGA was conducted as a function of hydration under uniaxial and biaxial stretch and by a novel “beach ball” inflation technique. The presence of small amounts of moisture leads to a decrease in yield stress and a decrease in elongation at break. The above presentation suggests reproducible preparation and evaluation of spherical rupturable osmotic capsules."]},{"key":"dc:title","label":"Title","values":["Biodegradable, Liquid-Filled, Spherical Capsules With Pre-Determined Burst Times"]}]}],"canonical_facts":{"dc:creator":["Harish Jain, Krutika"],"dc:date.accessioned":["2017-10-09T16:54:55Z"],"dc:date.available":["2017-10-09T16:54:55Z"],"dc:date.issued":["2017-06"],"dc:description":["University of Minnesota M.S. thesis. June 2017. Major: Pharmaceutics. Advisor: Ronald Siegel. 1 computer file (PDF); ix, 121 pages."],"dc:description.abstract":["A biodegradable poly(lactic acid-co-glycolic acid) (PLGA) capsule is presented in a spherical geometry, which exploits the principle of osmosis as an internal program to achieve a delayed-burst release of its load. The capsule burst lag-time is accurately predicted by modeling the rate of water uptake by the capsule core as a function of the capsule shell thickness, radius of the capsule, core osmotic pressure and the membrane tensile strength. Elastoplastic and failure characterization of PLGA was conducted as a function of hydration under uniaxial and biaxial stretch and by a novel “beach ball” inflation technique. The presence of small amounts of moisture leads to a decrease in yield stress and a decrease in elongation at break. The above presentation suggests reproducible preparation and evaluation of spherical rupturable osmotic capsules."],"dc:identifier.uri":["http://hdl.handle.net/11299/190596"],"dc:language.iso":["en"],"dc:subject":["Burst-type","Chronopharmaceutics","Elasto-plastic","Mathematical Model","Osmotic pumps","PLGA"],"dc:title":["Biodegradable, Liquid-Filled, Spherical Capsules With Pre-Determined Burst Times"],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:19:54Z"}