Selective molecular transport in nanopore systems

A detailed characterization of the physics of novel nanopore systems has the potential to revolutionize water filtration, nanofluidics, and biomolecule detection technologies. I give my characterizations of five nanopore systems as my dissertation. First, I present my study of nanopores in polyethylene terephthalate (PET), revealing the mechanism for variance in current rectification based on cation species. Second, I demonstrate the mechanism of selective probe capture in bacterial toxin protein α-hemolysin (aHL) using dielectrophoresis. Third, I introduce the first simulation of molecular artificial water channel pillar[5]arene (PAP) and uncover the mechanics of its water transport and self-aggregation properties. Fourth, I characterize the water permeability and ion rejection of truncated human membrane protein aquaporin-1 (AQP) in simulation. Finally, I present MD simulation of truncated AQP as a voltage-gated ionic diode and as the functional element of a double-membrane ionic pump.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Physics

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2017

Author dc:creator

• Decker, Karl Steven

Contributors dc:contributor

• Aksimentiev, Aleksei
• Selvin, Paul R.
• Tajkhorshid, Emad
• Stack, John

• Molecular transport
• Nanopore
• Biomolecule
• Ion current
• Filtration

Statement dc:rights

• Copyright 2017 Karl Decker

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/98107

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/98107