Development of x-ray luminescence detection system and characterization of x-ray irradiated quantum dots for image-guided x-ray photodynamic therapy

The work in this thesis demonstrates X-ray luminescence (XL) detection system setup and XL quantification of X-ray irradiated quantum dots (QDs) to study efficiencies of X-ray photodynamic therapy (X-PDT). The XL detection system utilizes a light-sensitive electron-multiplying charge coupled device (EMCCD), a demagnifying (DM) image intensifier, and on optical lens to monitor XL signal emitted from the QDs. We used core-shell QDs and doped QDs to characterize their XL properties and absorption of X-ray photons. Along with the characterization of XL, the work eventually discusses potential applications of the system as a new biomedical theranostic modality. This study also demonstrates how well-controlled synthesis parameters of QDs such as elemental composition and dopant integration foreshow mechanisms of XL. Superimposed images of optical and XL signals are also presented to show potential fluorescence microscope imaging applications. Additionally, polydimethylsiloxane (PDMS)-based optical phantom with scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Bioengineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2017

Author dc:creator

• Yoon, Byung Hui

Contributors dc:contributor

• Meng, Ling-Jian

• X-ray
• X-ray luminescence
• Quantum dots
• Doped quantum dots
• Polydimethylsiloxane (PDMS)
• Optical phantom
• Scintillation
• Nanotechnology
• Radiology

Statement dc:rights

• Copyright 2017 Byung Hui Yoon

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/97318

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/97318