{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/97318"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/97318","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Development of x-ray luminescence detection system and characterization of x-ray irradiated quantum dots for image-guided x-ray photodynamic therapy","abstract":"The work in this thesis demonstrates X-ray luminescence (XL) detection system setup and XL quantification of X-ray irradiated quantum dots (QDs) to study efficiencies of X-ray photodynamic therapy (X-PDT). The XL detection system utilizes a light-sensitive electron-multiplying charge coupled device (EMCCD), a demagnifying (DM) image intensifier, and on optical lens to monitor XL signal emitted from the QDs. We used core-shell QDs and doped QDs to characterize their XL properties and absorption of X-ray photons. Along with the characterization of XL, the work eventually discusses potential applications of the system as a new biomedical theranostic modality. This study also demonstrates how well-controlled synthesis parameters of QDs such as elemental composition and dopant integration foreshow mechanisms of XL. Superimposed images of optical and XL signals are also presented to show potential fluorescence microscope imaging applications. Additionally, polydimethylsiloxane (PDMS)-based optical phantom with scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.","abstract_html":"The work in this thesis demonstrates X-ray luminescence (XL) detection system setup and XL quantification of X-ray irradiated quantum dots (QDs) to study efficiencies of X-ray photodynamic therapy (X-PDT). The XL detection system utilizes a light-sensitive electron-multiplying charge coupled device (EMCCD), a demagnifying (DM) image intensifier, and on optical lens to monitor XL signal emitted from the QDs. We used core-shell QDs and doped QDs to characterize their XL properties and absorption of X-ray photons. Along with the characterization of XL, the work eventually discusses potential applications of the system as a new biomedical theranostic modality. This study also demonstrates how well-controlled synthesis parameters of QDs such as elemental composition and dopant integration foreshow mechanisms of XL. Superimposed images of optical and XL signals are also presented to show potential fluorescence microscope imaging applications. Additionally, polydimethylsiloxane (PDMS)-based optical phantom with scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.","abstract_has_math":false,"creators":["Yoon, Byung Hui"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Meng, Ling-Jian"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-08-10T19:14:49Z","date_published":"2017-08-10T19:14:49Z","updated_at":"2026-07-22T22:24:32Z","subjects":["X-ray","X-ray luminescence","Quantum dots","Doped quantum dots","Polydimethylsiloxane (PDMS)","Optical phantom","Scintillation","Nanotechnology","Radiology"],"languages":["en"],"rights":["Copyright 2017 Byung Hui Yoon"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/97318","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Meng, Ling-Jian"]},{"key":"dc:creator","label":"Author","values":["Yoon, Byung Hui"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-08-10T19:14:49Z","2017-04-11","2017-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["X-ray","X-ray luminescence","Quantum dots","Doped quantum dots","Polydimethylsiloxane (PDMS)","Optical phantom","Scintillation","Nanotechnology","Radiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Byung Hui Yoon"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/97318"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The work in this thesis demonstrates X-ray luminescence (XL) detection system setup and XL quantification of X-ray irradiated quantum dots (QDs) to study efficiencies of X-ray photodynamic therapy (X-PDT). The XL detection system utilizes a light-sensitive electron-multiplying charge coupled device (EMCCD), a demagnifying (DM) image intensifier, and on optical lens to monitor XL signal emitted from the QDs. We used core-shell QDs and doped QDs to characterize their XL properties and absorption of X-ray photons. Along with the characterization of XL, the work eventually discusses potential applications of the system as a new biomedical theranostic modality. This study also demonstrates how well-controlled synthesis parameters of QDs such as elemental composition and dopant integration foreshow mechanisms of XL. Superimposed images of optical and XL signals are also presented to show potential fluorescence microscope imaging applications. Additionally, polydimethylsiloxane (PDMS)-based optical phantom with scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2017-08-10 without embargo terms","The student, Byung Hui Yoon, accepted the attached license on 2017-04-10 at 11:35.","The student, Byung Hui Yoon, submitted this Thesis for approval on 2017-04-10 at 11:50.","This Thesis was approved for publication on 2017-04-11 at 12:03.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10677 on 2017-08-10 at 13:39:01","Made available in DSpace on 2017-08-10T19:14:49Z (GMT). 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The XL detection system utilizes a light-sensitive electron-multiplying charge coupled device (EMCCD), a demagnifying (DM) image intensifier, and on optical lens to monitor XL signal emitted from the QDs. We used core-shell QDs and doped QDs to characterize their XL properties and absorption of X-ray photons. Along with the characterization of XL, the work eventually discusses potential applications of the system as a new biomedical theranostic modality. This study also demonstrates how well-controlled synthesis parameters of QDs such as elemental composition and dopant integration foreshow mechanisms of XL. Superimposed images of optical and XL signals are also presented to show potential fluorescence microscope imaging applications. Additionally, polydimethylsiloxane (PDMS)-based optical phantom with scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2017-08-10 without embargo terms","The student, Byung Hui Yoon, accepted the attached license on 2017-04-10 at 11:35.","The student, Byung Hui Yoon, submitted this Thesis for approval on 2017-04-10 at 11:50.","This Thesis was approved for publication on 2017-04-11 at 12:03.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10677 on 2017-08-10 at 13:39:01","Made available in DSpace on 2017-08-10T19:14:49Z (GMT). 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