The development of deoxynybomycins as potent and selective antibiotics against fluoroquinolone resistant bacteria

Antibiotic-resistant bacterial infections pose a real and increasing threat to public health and welfare. As bacteria continue to develop and spread resistance to currently used antibiotics it is of the upmost importance to develop new classes of antibiotics to combat them. Deoxnybyomycin (DNM), which has been previously found to be efficacious against fluoroquinolone resistant bacteria including S. aureus, is one such antimicrobial compound, and its further derivatization is reported herein. Derivatives of DNM had been previously synthesized possessing alkyl substitutions at four different positions. Described in Chapter 2 is the synthesis of several new DNM based compounds containing either previously unexplored polar functionality or new modifications to the five-membered ring. These compounds were tested against fluoroquinolone resistant and wild-type S. aureus, and the derivatives based on modifying the five-membered ring were found to maintain strong activity and selectivity against fluoroquinolone resistant bacteria possessing a S84L mutation in GyrA. The polar compounds were found to be less active against fluoroquinolone resistant S. aureus, but at least one was found to maintain a strong difference in selectivity

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2016

Author dc:creator

• Nakamura, Bradley A

Contributors dc:contributor

• Hergenrother, Paul J.

• Chemistry
• antibiotics
• resistant bacteria
• deoxynybomycin

Statement dc:rights

• Copyright 2015 Bradley A Nakamura

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/89155

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/89155