{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/89155"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/89155","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The development of deoxynybomycins as potent and selective antibiotics against fluoroquinolone resistant bacteria","abstract":"Antibiotic-resistant bacterial infections pose a real and increasing threat to public health and welfare. As bacteria continue to develop and spread resistance to currently used antibiotics it is of the upmost importance to develop new classes of antibiotics to combat them. Deoxnybyomycin (DNM), which has been previously found to be efficacious against fluoroquinolone resistant bacteria including S. aureus, is one such antimicrobial compound, and its further derivatization is reported herein. Derivatives of DNM had been previously synthesized possessing alkyl substitutions at four different positions. Described in Chapter 2 is the synthesis of several new DNM based compounds containing either previously unexplored polar functionality or new modifications to the five-membered ring. These compounds were tested against fluoroquinolone resistant and wild-type S. aureus, and the derivatives based on modifying the five-membered ring were found to maintain strong activity and selectivity against fluoroquinolone resistant bacteria possessing a S84L mutation in GyrA. The polar compounds were found to be less active against fluoroquinolone resistant S. aureus, but at least one was found to maintain a strong difference in selectivity","abstract_html":"Antibiotic-resistant bacterial infections pose a real and increasing threat to public health and welfare. As bacteria continue to develop and spread resistance to currently used antibiotics it is of the upmost importance to develop new classes of antibiotics to combat them. Deoxnybyomycin (DNM), which has been previously found to be efficacious against fluoroquinolone resistant bacteria including S. aureus, is one such antimicrobial compound, and its further derivatization is reported herein. Derivatives of DNM had been previously synthesized possessing alkyl substitutions at four different positions. Described in Chapter 2 is the synthesis of several new DNM based compounds containing either previously unexplored polar functionality or new modifications to the five-membered ring. These compounds were tested against fluoroquinolone resistant and wild-type S. aureus, and the derivatives based on modifying the five-membered ring were found to maintain strong activity and selectivity against fluoroquinolone resistant bacteria possessing a S84L mutation in GyrA. The polar compounds were found to be less active against fluoroquinolone resistant S. aureus, but at least one was found to maintain a strong difference in selectivity","abstract_has_math":false,"creators":["Nakamura, Bradley A"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Hergenrother, Paul J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-03-02T20:24:17Z","date_published":"2016-03-02T20:24:17Z","updated_at":"2026-07-22T22:26:32Z","subjects":["Chemistry","antibiotics","resistant bacteria","deoxynybomycin"],"languages":["en"],"rights":["Copyright 2015 Bradley A Nakamura"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/89155","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hergenrother, Paul J."]},{"key":"dc:creator","label":"Author","values":["Nakamura, Bradley A"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-03-02T20:24:17Z","2018-03-03T10:15:30Z","2015-12-08","2015-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry","antibiotics","resistant bacteria","deoxynybomycin"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Bradley A Nakamura"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/89155"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Antibiotic-resistant bacterial infections pose a real and increasing threat to public health and welfare. As bacteria continue to develop and spread resistance to currently used antibiotics it is of the upmost importance to develop new classes of antibiotics to combat them. Deoxnybyomycin (DNM), which has been previously found to be efficacious against fluoroquinolone resistant bacteria including S. aureus, is one such antimicrobial compound, and its further derivatization is reported herein. Derivatives of DNM had been previously synthesized possessing alkyl substitutions at four different positions. Described in Chapter 2 is the synthesis of several new DNM based compounds containing either previously unexplored polar functionality or new modifications to the five-membered ring. These compounds were tested against fluoroquinolone resistant and wild-type S. aureus, and the derivatives based on modifying the five-membered ring were found to maintain strong activity and selectivity against fluoroquinolone resistant bacteria possessing a S84L mutation in GyrA. 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As bacteria continue to develop and spread resistance to currently used antibiotics it is of the upmost importance to develop new classes of antibiotics to combat them. Deoxnybyomycin (DNM), which has been previously found to be efficacious against fluoroquinolone resistant bacteria including S. aureus, is one such antimicrobial compound, and its further derivatization is reported herein. Derivatives of DNM had been previously synthesized possessing alkyl substitutions at four different positions. Described in Chapter 2 is the synthesis of several new DNM based compounds containing either previously unexplored polar functionality or new modifications to the five-membered ring. These compounds were tested against fluoroquinolone resistant and wild-type S. aureus, and the derivatives based on modifying the five-membered ring were found to maintain strong activity and selectivity against fluoroquinolone resistant bacteria possessing a S84L mutation in GyrA. The polar compounds were found to be less active against fluoroquinolone resistant S. aureus, but at least one was found to maintain a strong difference in selectivity","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2017-12-01","The student, Bradley Nakamura, accepted the attached license on 2015-12-08 at 10:09.","The student, Bradley Nakamura, submitted this Thesis for approval on 2015-12-08 at 10:15.","This Thesis was approved for publication on 2015-12-08 at 15:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8965 on 2016-03-02 at 14:07:52","Made available in DSpace on 2016-03-02T20:24:17Z (GMT). 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