Micrometer-scale chemical analysis using heated AFM cantilever and mass spectrometer

This thesis presents the development of a micrometer-scale chemical analysis method using a heated atomic force microscope(AFM) cantilever and mass spectrometer. Simulations investigate the underlying transport mechanisms within the system and the impact of various design parameters. The way to optimize the system is suggested based on the simulation results. A heated microcantilever is used to thermally desorb a micrometer-sized sample by applying thermal energy. Thermally desorbed species are transported through the micro capillary to the vacuum chamber and are deposited onto the plate inside the chamber. The collected species on the plate can be analyzed by a mass spectrometer or fluorescence microscope. The microcantilever is resistively heated and can be operated up to 1000 °C, which enables applications to various samples with a high decomposition or boiling temperature. In the present work, a caffeine sample and rhodamine B sample were successfully analyzed. The caffeine sample was detected by MALDI mass spectrometry, and rhodamine B sample was detected by fluorescence microscopy.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Mechanical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Moon, Hyunkyu

Contributors dc:contributor

• King, William Paul

• atomic force microscopy (AFM)
• mass spectrometer (MS)
• Matrix-assisted laser desorption/ionisation (MALDI)
• heated cantilever
• chemical identification

Statement dc:rights

• Copyright 2015 Hyunkyu Moon

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/88317

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/88317