Studying the interface between DNA and inorganic nanoparticles to control shape and anisotropicity

Nanomaterials with their unique optical, electrical and chemical properties are promising candidates for various applications ranging from catalysis to biomedicine. To realize the full potential of nanomaterials, it is important to demonstrate fine control over nanoparticle morphology, and precise spatial control of the position and orientation between multiple nanoparticles. These issues in the field of nanomaterials are challenging to address and would greatly benefit from the precision and programmability of biomaterials such as DNA. In order to better apply DNA to solve issues in the field of nanomaterials, it is necessary to understand the interactions between DNA and metal nanoparticles. This thesis demonstrates the use of DNA to offer control over nanoparticle morphology and anisotropicity. The role of DNA in programming the growth of nanoparticles into different shapes were investigated through ex situ and in situ experiments. The optimal pH range for DNA to guide nanoparticle growth was investigated. In addition to shape control, precise positioning and assembly of nanoparticles are also important. Anisotropic nanoparticles have been synthesized through competition of DNA and another hydrophobic ligand on the nanoparticle. Finally, the stabilities of DNA in the presence of nanoparticles were further investigated to understand the conditions suitable for the DNA-nanoparticle hybrids to be used for various applications.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Tan, Li Huey

Contributors dc:contributor

• Lu, Yi
• Braun, Paul V.
• Cheng, Jianjun
• Murphy, Catherine J.

• Deoxyribonucleic acid (DNA)
• nanoparticle
• shape control
• anisotropicity

Statement dc:rights

• Copyright 2015 Li Huey Tan

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/88262

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/88262