Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Spatial control"”.
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Spatial control of cavitation in therapeutic ultrasound
… concern is to induce cavitation in perfectly controlled locations in the field; this means specifically to be able to achieve cavitation threshold at the geometrical focus of the transducer without stimulating its near field. In this study, we make use of dual-frequency methods to …
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Toward spatial control of gold nanorod surface functionalization
… chemical nature of the surface is understood and controlled. GNRs can enhance various photophysical properties of molecules. In the case of two-photon absorption (TPA), cross-section enhancements have been shown to increase with strong distance-dependence. Here, a dual approach for the conjugation …
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Mechanisms underlying spatial control of exit from mitosis
… localization of the essential phosphatase Cdc 4. Control of the MEN by spindle position is established through MEN inhibitory signals in the mother cell compartment (such as the kinase Kin4), MEN promoting signals in the bud (such as Ltel) and a GTPase sensor (Tem1) that moves between them. While …
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Spatial control of ligand presentation on biomaterial surfaces
… It has therefore been hypothesized that controlled clustering of 2, 3.....n integrins might be achieved by controlling the spatial distribution of adhesion ligands on biomaterial surfaces. Substrates were prepared on which cell-surface interactions are controlled by modifying non-adhesive …
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Medium-Sized Ring Compounds and Spatial Control of Basicity
Made available in DSpace on 2014-12-09T17:35:03Z (GMT). No. of bitstreams: 1 6503580.pdf: 5272515 bytes, checksum: f05bdc903e53bc540c7b58f6f1471098 (MD5) Previous issue date: 1964
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Spatial Control of CDC42 Activation Regulates Cell Width and Growth Zone Formation
… geometry makes it a good system to study the control of cellular dimensions. Here I used the width of the cell as a model for the control of growth zone size. To identify genes that influence cell size I carried out a near-genome-widescreen for mutants wider than wild-type cells. I found …
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Patterning planar surfaces with motor proteins: Towards spatial control over motile microtubules
A major challenge in nanotechnology is the spatially controlled transport of cargo on the nanometer scale. The use of a nanoscale transport system based on molecular motors and filaments of the cytoskeleton proved as a promising approach to this problem. Therefore, the objective of this work was to …
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Fabrication of tissue engineering scaffolds with spatial control over architecture and cell-matrix interactions in 3D
… of this work is the demonstration of spatial control over architecture and surface chemistry in three-dimensional tissue engineering scaffolds. Tissues are characterized by a well-defined three-dimensional arrangement of cells. Spatial control of scaffold elements may be used to …
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Engineering of tools for De Novo Assembly of Human Cells
… as microfluidics and 3D bioprinting, provide spatial control by patterning cell types with high resolution, but face challenges in reproducing physiologically accurate cell types and interactions. Bottom-up methods, such as organoids, induce pluripotent cells to differentiate into aggregates …
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The use of ultrasound to facilitate the delivery of genetic-based therapeutic strategies
… would be followed with ultrasound-directed spatial control of gene expression.
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Feedback Control of Phased Array Electromagnetic Hyperthermia Using MRI Temperature Mapping
This work focuses on closed loop control of microwave hyperthermia using noninvasive MRI thermometry. The following developments are reported here: (1) An integrated MR-microwave hyperthermia system intended for small animal studies was designed and built. (2) A new technique is presented that …
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In vivo activation and biocompatibility of a MEMS microreservoir drug delivery device
Temporal and spatial control over the delivery of therapeutic compounds is an important, fertile, and rapidly advancing field of study in medicine. This work describes the advancement of a new technology of drug delivery from a benchtop prototype releasing tracer molecules to an implantable device …
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The Regulation of Cellular Localization of Both Active and Inactive ERK1/2
… the question is the ligand and context-specific spatial control of ERK1/2 in the cell. By confining activity of ERK1/2 to localized regions, cells modulate signaling output. To gain insights into the spatial control of ERK1/2 I examined nuclear import of ERK2 mutants, the interactions of ERK2 …
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Constructing the Navajo Capital: Landscape, Power, and Representation at Window Rock
"This dissertation considers the physical and spatial ordering of buildings and people---the landscape---to follow political and social agendas. In this study, I demonstrate how Window Rock, a multi-million-dollar project of the Public Works Administration (PWA), was used as the centerpiece for OIA …
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Macromolecular recognition in the cytochrome P450(cam) enzyme system
… transformations requiring precise temporal and spatial control of reactivities. Cytochrome P-450$\sb{\rm cam}$ catalyzes the regio- and stereo-specific hydroxylation of camphor to form 5-exo-hydroxycamphor. The two reducing equivalents required for this reaction are supplied physiologically by …
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Studying the interface between DNA and inorganic nanoparticles to control shape and anisotropicity
… it is important to demonstrate fine control over nanoparticle morphology, and precise spatial control of the position and orientation between multiple nanoparticles. These issues in the field of nanomaterials are challenging to address and would greatly benefit from the precision and …
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Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways
… of a phosphopeptide with temporal and spatial control is accomplished by the photolysis of a photolabile precursor, a caged phosphopeptide. The synthesis and application of NI-Fmoc-protected 1-(2-nitrophenyl) ethyl (NPE) caged phosphothreonine, serine, and tyrosine building blocks …
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Manipulating fluids and fields In multimaterial fibers
… as a method to fabricate fibers with precise spatial control of a broad range of materials, such as polymers and metals, enables the integration of new functionalities into these traditionally single material tools. In this thesis we investigate the use of thermally drawn fibers as a means to …
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Strategies to design and optimize natural polymers as biomaterial inks for musculoskeletal tissue engineering applications
… techniques to develop scaffolds with precise spatial control for biomedical applications. Among the existing technologies, extrusion-based bioprinting gained an increased interest in fabricating complex tissue constructs due to its high throughput and versatility in processing materials with a …
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DNA Directed Organic Semiconductor Interactions Controlling Excitons, Charge Transfer States, and Singlet Fission
… the relative geometries between molecules. Yet, control over spatial assembly of organic semiconductors is challenging. Large aromatic molecules will self-assemble into extended structures with no size or positional control. Deterministic interactions between two different semiconductor molecules …
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