Applications of quantitative phase imaging for pathology

Prostate cancers, which account for 14% of all cancers diagnosed in the United States, and colorectal cancers, which account for 8.2% of all cancers, present a unique set of diagnostic problems [1]. In the case of prostate cancer, overdiagnosis of early-stage disease and poor accuracy at characterizing high-risk disease, especially when diagnosed at the intermediate stage, are major problems. A new prognostic method is thus necessary for improving prostate cancer management. In the case of colorectal cancer, early disease diagnosis is of critical importance for the purpose of reduction in disease-specific death rates. An automated screening tool which identifies cases that warrant further examination by the pathologist would assist in the implementation of a wide-spread screening program. Quantitative phase imaging (QPI) of unstained tissue provides information on the refractive index distribution, or tissue morphology, with nanometer level sensitivity. Subtle morphological changes in both the epithelial and stromal regions of tissue, which are not visible in stained tissue sections used in current pathological settings, can be measured using QPI. Thus QPI would be a valuable addition to current diagnostic pathology.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Bioengineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Sridharan, Shamira

Contributors dc:contributor

• Popescu, Gabriel
• Kajdacsy-Balla, André
• Bhargava, Rohit
• Boppart, Stephen A.

• quantitative phase imaging (QPI)
• phase contrast
• quantitative diagnosis
• biomarker
• prostate cancer
• colorectal cancer
• recurrence
• scattering
• anisotropy

Statement dc:rights

• Copyright 2015 Shamira Sridharan

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/88244

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/88244