Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1378 for “"biomarker"”.
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Experiments on biomarker preservation
… that serve as approximate experiments on biomarker preservation. Furthermore, this dissertation includes a series of laboratory modeling experiments to determine the stability of ribonucleic acid (RNA) under early Mars-like conditions and groundtruthing experiments which complement ongoing …
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Proteomics for cancer biomarker discovery
… as it applies to early detection of cancer and biomarker discovery.
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Building bioinformatics solutions for biomarker identification
… systems to aid work in the field of biomarker discovery and diagnostic test development. The aim of the work was to develop a flexible data storage and analysis platform that would be capable of housing and working with data from a variety of modern biomarker analysis techniques. In …
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Microfluidic-based Fluorescence Detection for Biomarker Analysis
… of microfluidics and fluorescence detection for biomarker analysis. The first platform described here is to isolate CTCs with high purity by using 2-stage sorting technique and herringbone features for aliquot stretching, including axial and lateral mixing to spread cells. We achieved a roughly …
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Ovarian cancer serum biomarker discovery using proteomics
… Cancer antigen-125, the most widely used biomarker for ovarian cancer detection, lacks appropriate sensitivity and specificity. Thus, early biomarkers of the disease are urgently required. Proteomic analysis of human serum promises to be a valuable approach for the discovery of putative …
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Statistical Considerations in Designing for Biomarker Detection
The purpose of this project is to develop a statistical method for use in rapid detection of biological agents using portable gas chromatography mass spectrometry (GC/MS) devices. Of particular interest is 2,6-pyridinedicarboxylic acid (dipicolinic acid, or DPA), a molecule that is present at high …
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Single molecule methods for clinical biomarker quantification
… of disease. As our understanding of these biomarkers continues to advance, the ability to quantify low abundance biomarkers from small sample sizes has become increasingly important for characterizing new targets and expanding the range of available disease indicators. In addition to …
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Multiplexed angiogenic biomarker quantification on single cells
Clinical and biomedical research seeks single-cell quantification to better understand their roles in a complex, multi-cell environment. Recently, quantification of vascular endothelial growth factor receptors (VEGFRs) provided important insights into endothelial cell (EC) characteristics and …
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Multi-stakeholder collaborations & biomarker development and implementation
… have triggered a renewed focus on the role of biomarkers in drug development and clinical care. While many stakeholders, including industry, regulatory agencies, patients, academia, and payers, are involved in biomarker development and use, these stakeholders reside in functional siloes that …
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Identification of intravasation sites for metastatic biomarker development
… provide actionable therapeutic targets and novel biomarkers for disease stratification, with the central goal of improving patient outcomes from this work.
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Biomarker Discovery in Autoimmune Diseases: A Proteomics Approach
… discovery. Mass spectrometry-based proteomics biomarker discovery holds the ability to interrogate a constellation of proteins simultaneously in a high-throughput manner to uncover a panel of markers that are specific to the presence of a disease. However, the rate of introduction of novel …
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EVALUATING SOLUBLE AXL AS A BIOMARKER FOR GLIOBLASTOMA
<p>AXL, a receptor tyrosine kinase, is known to promote malignant phenotypes in various types of cancer. AXL overexpression is commonly observed in glioblastoma and correlates with a worse prognosis. Detectable in most biological fluids, the extracellular domain of AXL, sAXL, is the product of …
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HSP70: a therapeutic biomarker for treatment of glioma
… that HSP70 can be better therapeutic biomarker for treatment of glioma.
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Using biomarker data to monitor the HIV epidemic
… This dissertation will examine the way in which biomarker data can be used to monitor the HIV epidemic. There are two primary aims of this thesis: a) to investigate the use of biomarkers in quantifying the recency of HIV infection at individual level and b) to estimate quantities such as mean …
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Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
… Recently, liquid biopsy and circulating cancer biomarkers such as circulating tumor cells (CTC), extracellular vesicles (EV), and cell free DNA (cfDNA) have gained great attentions for early diagnosis, prognosis, and treatment monitoring of cancer patients because they can be accessed in less …
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Nucleobase deamination as a biomarker of inflammatory processes
… of ligation-mediated PCR. As an extension of the biomarker study, the effects of ONOO⁻ dose and dose-rate on the DNA damage and mutations induced in the supF gene were investigated. The observations suggest that both the dose and dose-rate at which a genetic target is exposed to ONOO⁻ …
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Statistical Methods For Biomarker Threshold Models in Clinical Trials
… subset of patients more, identified by a certain biomarker. The cut-point value defining patient subsets is often unknown. For this situation, the ordinary likelihood ratio test cannot be applied for testing treatment-biomarker interaction because of the model irregularities. We develop a residual …
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