In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production

As expected, both Ara-C and MMS treated mice had DNA and cellular damage. SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Trinachartvanit, Wachareeporn

Contributors dc:contributor

• Francis, Bettina M.

• Health Sciences, Nutrition

Language dc:language

eng

Identifier

(MiAaPQ)AAI3153443

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/87843