{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87843"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87843","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production","abstract":"As expected, both Ara-C and MMS treated mice had DNA and cellular damage. SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.","abstract_html":"As expected, both Ara-C and MMS treated mice had DNA and cellular damage. SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.","abstract_has_math":false,"creators":["Trinachartvanit, Wachareeporn"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Biology","degree_department":null,"school":null,"contributors":["Francis, Bettina M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T16:59:58Z","date_published":"2015-09-28T16:59:58Z","updated_at":"2026-07-22T22:26:31Z","subjects":["Health Sciences, Nutrition"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3153443"],"render_values":[{"text":"(MiAaPQ)AAI3153443","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87843","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Francis, Bettina M."]},{"key":"dc:creator","label":"Author","values":["Trinachartvanit, Wachareeporn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T16:59:58Z","10000-01-01","2004"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87843","(MiAaPQ)AAI3153443"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["As expected, both Ara-C and MMS treated mice had DNA and cellular damage. SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.","Made available in DSpace on 2015-09-28T16:59:58Z (GMT). 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SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.","Made available in DSpace on 2015-09-28T16:59:58Z (GMT). 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