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University of Illinois at Urbana-Champaign
Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis
Abstract
dc:descriptionWe identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Veterinary Pathobiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Butterfield, Russell James
- Contributors dc:contributor
-
- Schook, Lawrence B.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3023026
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/87617