{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87617"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87617","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis","abstract":"We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype.","abstract_html":"We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype.","abstract_has_math":false,"creators":["Butterfield, Russell James"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Veterinary Pathobiology","degree_department":null,"school":null,"contributors":["Schook, Lawrence B."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T16:21:33Z","date_published":"2015-09-28T16:21:33Z","updated_at":"2026-07-22T22:26:30Z","subjects":["Health Sciences, Immunology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3023026"],"render_values":[{"text":"(MiAaPQ)AAI3023026","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87617","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Schook, Lawrence B."]},{"key":"dc:creator","label":"Author","values":["Butterfield, Russell James"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T16:21:33Z","10000-01-01","2001"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Pathobiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87617","(MiAaPQ)AAI3023026"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. 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Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype.","Made available in DSpace on 2015-09-28T16:21:33Z (GMT). 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