Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes

To test whether the LVA Ca$\sp{2+}$ channel contains β subunit, I studied the ability of an AS ON (\rmβ\sb{all}) targeting a common sequence of all four β subunits to modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were inhibited by AS-\rmβ\sb{all}. These results support the idea that atrial T-type calcium channel is encoded by a member of the \rmα\sb{1E} calcium channel genes and is composed of at least the \rmα\sb{1E} and β subunits.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Molecular and Integrative Physiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Chen, Chien-Chang

Contributors dc:contributor

• Best, Philip M.

• Biology, Animal Physiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI9904405

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/87264