Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"T-Type"”.
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T-type calcium channels and human mesangial cell proliferation
… of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression and functional significance in MC is not known. The aim of this thesis was to investigate …
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Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure
Alcohol is the third highest risk factor for health related problems in the world and leads to over two million deaths per year. Individuals abusing alcohol frequently cycle between drinking and withdrawal states, which among other adverse side effects can induce withdrawal seizures. Alcohol …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… of this study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in the heart is Cav3.1/α1G, and therefore we used Cav3.1/α1G transgenic (TG), knockout (-/-) and wild type mice respectively to define the role …
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Divalent Effects on Permeatin and Gating of T-type calcium channels
… decades has gone into discovering the different types of voltage gated calcium channels and their permeation and gating properties. Many models have been proposed to explain how ions permeate through calcium channels. The second chapter of this thesis uses a 2 binding site 3 barrier model of …
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
… in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if they are regulatory targets of vasoactive signaling pathways, and to reveal their …
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… rhythms, with low-threshold, transient (T-type) Ca2+ channels participating in this activity. The focus of this thesis is on the molecular and physiological alterations in thalamic T-type Ca2+ channels arising from neuronal insults that result in the generation of abnormal brain rhythms. …
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Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
T-type voltage-gated calcium (Ca2+) channels play critical roles in controlling neuronal excitability, firing patterns, and synaptic plasticity, although the mechanisms and extent to which T-type Ca2+ channels are modulated by G-protein coupled receptors (GPCRs) remains largely unexplored. …
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Sensorless control of an interior permanent magnet synchronous motor with a three level t-type inverter
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
Cardiac myocytes express two types of voltage operated calcium currents, a high voltage activated (HVA) L-type, and a low voltage activated (LVA) T-type. Influx of calcium into the cell through the L-type channel is responsible for excitation-contraction coupling in the heart. The T-type calcium …
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IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS
… mediated by Ca 2+ influx through Ca v 3.2 T - type voltage - gated calcium channel (CACNA1H). This finding establish es a key functional role for Ca v 3.2 in control of HCC proliferation, and furthermore establishes this transmembrane protein complex as a main target for HCC - specific AM RF …
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Modulation of calcium channel expression in cardiac myocytes of rats during growth hormone-induced growth or normal postnatal development
… were studied using patch-clamp techniques. T-type Ca$\sp{2+}$ current density of atrial myocytes was found to be positively correlated with the plasma growth hormone levels and the growth rate of atrial myocytes in normally developing Sprague-Dawley rats, adult Wistar-Furth rats made to …
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Towards High Efficiency and High Power Density Converter: System Level Design, Modulation, and Active EMI Filters
… inverter application, three-level (3-L) T-type neutral-point-clamped (TNPC) inverters has higher efficiency and lower total harmonic distortion (THD) compared to two-level inverter. Hybrid switch concept combines the benefit of both silicon carbide (SiC) MOSFET and Si IGBT. By applying …
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CaV3.2 Channels and BKCa-Mediated Feedback in Vascular Smooth Muscle
The vascular T-type Ca2+ channel, CaV3.2, regulates arterial tone by triggering Ca2+ sparks and activating large conductance Ca2+-activated K+ (BKCa) channels. Despite being an integral element of an arterial feedback loop, little is known of its regulation and how key receptors and signaling …
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Ethosuximide stabilizes sleep-related oscillations and reduces sleep fragmentation during alcohol withdrawal
… importantly, non-REM (NREM) stages of sleep. T-type calcium channels are an important component of the cellular processes that generate and maintain SROs. In two complementary studies, we examined the effects of ethosuximide (ETX), a purported T-type calcium current inhibitor, and genetic …
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… the molecular mechanism of a selective T-type calcium channel blocker. Our data demonstrated a mix of loss- and gain-of-function in the CaV2.1 channel mutant P2455H, and a gain-of-function in a CaV3.1 channel variant (R706Q). For the CaV3.2 channel mutants, some presented a …
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Recurrent Streptococcal Pharyngotonsillitis Studies on etiology and treatment
… was defined as presence of GAS of the primary T-type within two weeks after completing therapy. 239 patients with GAS pharyngotonsillitis were treated with pcV for ten days. 53 patients with bacterial failure were randomized to treatment with either pcV or clindamycin and were then followed for …
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Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus
… reticular nucleus (TRN) generate distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory thalamic nuclei underlie the generation of sleep spindles, the mechanisms regulating slow (<1 >Hz) forms of thalamic oscillations are poorly understood. …
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Nonlinear finite element analysis of tubular joints
… at the ultimate state, the stiffness of the T-type joints at different load levels, the real failure modes of tubular joints under external loads and the assessment of the safety margins in the design process.
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Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
… These results support the idea that atrial T-type calcium channel is encoded by a member of the $\rm\alpha\sb{1E}$ calcium channel genes and is composed of at least the $\rm\alpha\sb{1E}$ and $\beta$ subunits.
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Modulation of Axonal Transmission by Metabolic Stress
… at high temperatures that could be caused by a T-type calcium channel that may improve high-frequency firing. At high temperatures, we exposed the DCMD axon to cadmium and nickel, both calcium channel blockers, and observed a decrease in CV with a larger effect size for high-frequency APs. Cadmium …
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