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University of Illinois at Urbana-Champaign
Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice
Abstract
dc:descriptionThese experiments have demonstrated that fragile X knockout mice are more susceptible than control animals to the chemoconvulsant PTZ as adults, but not as juveniles. Furthermore, the temporal progression suggests that there is a developmental involvement in this seizure susceptibility. The mechanism of the seizure susceptibility and temporal progression are areas for further study. With a greater understanding of this general hyperexcitability, more effective treatments for fragile X patients can be devised.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Molecular and Integrative Physiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Campos, Victor E.
- Contributors dc:contributor
-
- Best, Philip M.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3314737
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/87248