Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"hyperexcitability"”.
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Stretch induced hyperexcitability of mice callosal pathway
Memory and learning are thought to result from changes in synaptic strength. Previous studies on synaptic physiology in brain slices have traditionally been focused on biochemical processes. Here, we demonstrate with experiments on mouse brain slices that central nervous system plasticity is also …
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… system (CNS) disorders involving neuronal hyperexcitability: a chemically-induced model of temporal lobe epilepsy (TLE), and a model of chronic alcohol withdrawal following repeated intermittent exposures to ethanol. In particular, one T-type Ca2+ channel isoform, CaV3.2, was investigated …
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The Emergence of Network Hyperexcitability and Functional Impairment in a Mouse Model of Alzheimer’s Disease
… been shown to induce synaptic dysfunction and hyperexcitability in the hippocampus. This thesis aimed to elucidate the emergence of hippocampal hyperexcitability and network dysfunction as a consequence of genotype-driven Aβ pathophysiology in a mouse model of AD. To this end, both acute ex …
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A Role For Epac1 and Epac2 In Nociceptor Hyperexcitability and Chronic Pain After Spinal Cord Injury
… role in the maintenance of persistent nociceptor hyperexcitability and chronic pain after SCI.</p> <p>Using both a T9 SCI mouse model and a T10 SCI rat model, we employed behavior assays and electrophysiological techniques to characterize the role of EPAC1 and 2 in SCI-induced pain. We also used …
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Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons
… inhibitory circuits in the brain, which leads to hyperexcitability and appearance of seizures. Current treatment relies on the use of antiepileptic drugs (AEDs), but these only treat the symptoms, not affect the causes of the disease, and trigger undesirable side effects because of their systemic …
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Antisense Reduction of the Protein Tau Attenuates Neuronal Hyperexcitability and Permits Clearance of Intraneuronal Tau Accumulations in vivo
… of reducing murine tau in the context of hyperexcitability since aberrant neuronal excitability has been linked to AD pathogenesis, both in humans and in amyloid-beta depositing mouse models. We found that mice with reduced tau had significantly less severe seizures than control mice, …
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OPTICALLY-INDUCED POPULATION DISCHARGE THRESHOLD TESTING: A NOVEL INVESTIGATION OF A MURINE MODEL OF ALCOHOL WITHDRAWAL INDUCED CNS HYPEREXCITABILITY
… (CNS) is described as being hyperexcitable. Hyperexcitability is a consequence of homeostatic pressure to compensate for alcohol’s potentiation of inhibitory systems. When the drug is removed from the system the compensatory changes in excitability are revealed leading to excess activity. The …
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… disease (AD) often exhibit neuronal network hyperexcitability, particularly in the CA3 region of the hippocampus, in the years preceding AD diagnosis, suggesting that aberrant network activity might contribute to the pathogenesis of AD. Recently, the microtubule-binding protein tau has been …
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An Examination of the Mechanisms of Neocortical Network Excitability in a Mouse Model of Fragile X Syndrome
… to underlie many autism spectrum disorders. The hyperexcitability in the Fmr1 KO may reflect a shift in E/I balance. However, despite the evidence for hyperexcitability, no studies have previously examined basal circuit function in the Fmr1 KO. In this study, I report that neocortical networks …
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Ampa Receptor Dysregulation And Therapeutic Interventions In A Mouse Model Of Cdkl5 Deficiency Disorder
… However, underlying mechanisms of what causes hyperexcitability and neurological deficits in CDD is poorly understood. We investigated the novel Cdkl5R59X mouse (R59X), and observed that mutant mice have social interaction and memory deficits, and decreased latency to seizure after …
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Postnatal development of the somatosensory cortex in a rat model of Fragile X Syndrome
… which could be underpinned by cortical hyperexcitability. Despite extensive research, currently there are no effective therapies targeting the underlying mechanisms, which could be due to species differences and limited understanding of how cortical dysfunction arises during development. …
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A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
… Nav1.7 excitability, though the source of this hyperexcitability remains to be discovered. Here, we introduced a homologous isoleucine to valine mutation (residue 22) in the ancestral bacterial channel, NavAb, and present a X-ray crystallography structure of the mutant channel. Small shifts in …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… sensitization is associated with cocaine-induced hyperexcitability of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and …
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The investigation of the neuronal and synaptic defects in early stage of amyloid-beta pathology
… so far. However, emerging evidence suggests that hyperexcitability precedes other symptoms by decades in patients and further accelerates the disease progression. Interestingly, treatment with an antiepileptic drug, levetiracetam, has shown promise in slowing down cognitive decline in both …
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Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice
… With a greater understanding of this general hyperexcitability, more effective treatments for fragile X patients can be devised.
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
… failed to reduce high potassium-induced hyperexcitability in slices from PPARγ neuronal knock out (NKO) mice. These results support the hypothesis that activation of PPARγ via pioglitazone attenuates various parameters of high potassium-induced hyperexcitability. The effectiveness in this …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… in neuropathic pain behaviors and a reduction in hyperexcitability of dorsal horn neurons in rats. Compounds that reduce ROS and lipid peroxidation are able to reduce measures of chronic neuropathic pain. Mechanical allodynia was reduced in chronic SCI rats with the intrathecal administration of …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… These contused animals exhibited spinal hyperexcitability during extracellular single-unit electrophysiological spinal recordings from the dorsal horn of the lumbar enlargement (below-level), thoracic cord (at-level; immediately rostral to injury site), and brachial enlargement (above …
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Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain
… that induces alterations that drive hyperexcitability, such as enhanced DSFs, and thereby potentiates ongoing activity in nociceptors, as well as to determine the alterations that contribute to nociceptor hyperactivity associated with postsurgical pain.</p> <p>A combination of …
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Pharmacological determinants of oxaliplatin neurotoxicity in patients undergoing cancer chemotherapy
… infusions on the pharmacokinetics, motor nerve hyperexcitability and acute neurotoxicity symptoms of oxaliplatin in patients were evaluated. The impact of calcium and magnesium ions on the in vitro degradation of oxaliplatin was also studied. A separate prospective observational cohort study was …
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