Cardiac Vasoactive Peptides in Hypertrophic Cardiomyopathy of Cats

In conclusion, ANP and BNP are normally produced and stored in the atria. With HCM, significant peptide and mRNA expression of BNP is found in the ventricles, while protein and gene expression of ANP remains mainly in the atria. This pattern agrees with increases in plasma concentrations of both peptides in cats with HCM, and suggests that BNP may be a more sensitive and specific plasma marker of feline HCM than ANP. Endothelin is expressed and produced throughout the cardiac tissue. Although plasma concentrations of ET-1 are known to be significantly higher in feline HCM than normal cats, it is probably due to noncardiac sources. The lack of detectable vasopressin expression suggests that vasopressin is not produced in significant amounts in feline cardiac tissue, contrasting with previous studies performed in rats.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Clinical Medicine

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Biondo, Alexander Welker

Contributors dc:contributor

• Philip F. Solter

• Biology, Veterinary Science

Language dc:language

eng

Identifier

(MiAaPQ)AAI3101799

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/87125