Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"HCM"”.
-
Accounting for midblock pedestrian activity in the HCM 2010 urban street segment analysis
… Chapter of the 2010 Highway Capacity Manual (HCM 2010) provides a methodology for analyzing automobile performance on signalized roadway segments within an urban roadway network. The methodology involves applying a platoon dispersion model to: a) predict the vehicle arrival flow profiles at a …
-
A Comparative Analysis of Weaving Areas in HCM, TRANSIMS, CORSIM, VISSIM and INTEGRATION
Traffic simulation is a powerful tool that provides transportation engineers with the ability to test the feasibility and performance of a system before it is implemented and also helps in optimizing the proposed system. Over the past twenty years significant amount of work has been conducted on …
-
Comparison of stopped delay between field measurements and HCM 2010 estimations at actuated signalized intersections
… few studies have been performed to validate the HCM delay estimation model. This thesis aims to study the accuracy of the HCM 2010 delay estimation methodology for actuated signalized intersections using field data. The HCM stopped delay estimates were statistically compared with the field …
-
MOLECULAR DISSECTION OF CARDIOMYOPATHY
Hypertrophic (HCM) and dilated cardiomyopathy (DCM) are inherited cardiac conditions with marked genetic heterogeneity. The genetic aetiology of HCM and DCM in Singapore and European was broadly similar but Singapore Chinese HCM patients frequently have fewer clinically actionable disease variants, …
-
Metabolic alterations in patients with heart disease
… failure (CHF) and hypertrophic cardiomyopathy (HCM) are still associated with significant morbidity and mortality. These patients often have a significant limitation in their exercise capacity. We showed that there are widespread abnormalities of both systolic and diastolic function in HCM …
-
Cardiac Vasoactive Peptides in Hypertrophic Cardiomyopathy of Cats
… normally produced and stored in the atria. With HCM, significant peptide and mRNA expression of BNP is found in the ventricles, while protein and gene expression of ANP remains mainly in the atria. This pattern agrees with increases in plasma concentrations of both peptides in cats with HCM, and …
-
Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease of the myocardium characterized by left ventricular hypertrophy and myofibrillar disarray. HCM is considered the most common cause of sudden cardiac death in young athletes. Mutations of the myosin-binding protein C (cMyBP-C) have …
-
Clinical and Molecular Overview of Hypertrophic Cardiomyopathy through JPH-2 Mutations and Presentation in Clinical Case Study
Hypertrophic Cardiomyopathy (HCM) is a disease which presents a distinct morphological change in cardiac tissue. Pathology of the disease widely ranges from being largely asymptomatic to the sudden onset of cardiac death. The disease's etiology stems from genetic mutations in various components of …
-
Ethnic differences in Cardiac Adaptation to Exercise
… black patients with hypertrophic cardiomyopathy (HCM). Any healthy subject exhibiting a mLVWT of >11mm (females) or >13mm (males), underwent comprehensive examination to look for phenotypic features of HCM. Male athletes were followed up for 69.7±29.6 months. Results BAs demonstrated a greater …
-
Field measurement of ideal saturation flow rate from the highway capacity manual
… analyses performed with Highway Capacity Manual (HCM), the Pennsylvania Department of Transportation (PENNDOT) District 12-0 uses an ideal saturation flow rate of 1800 pcphgpl, which is less than the default value of 1900 pcphgpl provided by HCM. This is to account for the less aggressive …
-
Development and Evaluation of a Simulation System Based Upon Standard Pedestrian Thoroughfare Methodologies
… incorporates the Highway Capacity Manual 2000 (HCM) (Transportation Research Board, National Research Council [TRB], 2000a) methodologies into a ProModel simulation and then compares and contrasts the results of the HCM calculations with the ProModel simulation.
-
Queue predictions at temporary work zones: modification and testing of an existing spreadsheet
… are based on the 1994 Highway Capacity Manual (HCM, 1994). The scope of this research pertains only to the queue estimation worksheet of that spreadsheet tool, herein referred to as the OkDOT baseline version. This tool, based on input-output logic, is simple to understand and use. Preliminary …
-
Plasma N-terminal Proatrial Natriuretic Peptide Concentration in Cats with Hypertrophic Cardiomyopathy
… from cats with hypertrophic cardiomyopathy (HCM). Secondarily, we wished to evaluate the relationship between [Nt-proANP] and echocardiographic variables. Methods: Venous blood samples were obtained from seventeen cats with HCM and from nineteen healthy cats. Plasma [Nt-proANP] was determined …
-
Cardiac Biomarkers in Hyperthyroid Cats
… Twenty-three hyperthyroid cats, 19 cats with HCM without congestive heart failure, and 19 euthyroid, normotensive healthy cats eight years of age or older. Fourteen of the hyperthyroid cats were re-evaluated three months after administration of 131I. Methods: A complete history, physical …
-
Mechanical Property and Phenotype Characterization of an in vitro Model for Afterload-triggered Cardiac Hypertrophy
<p>Hypertrophic Cardiomyopathy (HCM) is an inherited cardiomyopathy disease that affects approximately 1 in 500 to 1 in 200 people. Although abundant evidence has shown that HCM is related to sarcomere genetic mutations, recent research has also revealed that conditions that increase cardiac …
-
Haploinsufficiency of Cardiac Myosin Binding Protein-C in the Development of Hypertrophic Cardiomyopathy
… cardiomyopathies. Hypertrophic Cardiomyopathy (HCM) is characterized by left ventricular wall thickening, diastolic dysfunction, and sarcomere disarray. Mutations in sarcomeric protein encoding genes have been established as causative for HCM.</p><p>The gene MYBPC3, encoding cardiac myosin …
-
Development of Arrival-Type-Based Uniform Delay Models for Signalized Intersections
… models are the same as those required by the HCM. Comparison of field data with the results from the proposed models as well as the HCM showed that the new models predict the delay more precisely.
-
Development of a methodology for measuring delay-based passenger car equivalent for heavy vehicles at signalized intersections
… procedures, the 1985 Highway Capacity Manual (HCM) and the 1994 HCM were found to be deficient for estimating the effects of heavy vehicles.
-
Effect of ivabradine, a novel I<sub>f</sub> current inhibitor, on dynamic obstruction of the left ventricular outflow tract in cats with preclinical hypertrophic cardiomyopathy: a single-dose study
… subset of cats with hypertrophic cardiomyopathy (HCM) develop dynamic obstruction of the left ventricular outflow tract and mitral regurgitation secondary to hypertrophy of the left ventricle and systolic anterior motion (SAM) of the mitral valve. This leads to an increase in left ventricular …
Page 1 of 4