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University of Illinois at Urbana-Champaign
Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
Abstract
dc:descriptionThis dissertation elaborates on M2's molecular functioning as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a novel immunoregulatory function. Data contained within this dissertation provides insight into the molecular mechanism of an ER-localized protein, and its impact on cytoplasmic signaling pathways within the context of an anti-viral immune response.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Microbiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Hinthong, Olivia
- Contributors dc:contributor
-
- Joanna Shisler
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3455728
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/86716