Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Cellular Trafficking"”.
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Cellular Trafficking of Single and Multistage Vectors
… this study we investigated the intra and inter cellular trafficking of the multistage system in endothelial cells bringing evidence of its bio-compatibility as well as its ability to perform multiple intra and inter cellular tasks. Once internalized in cells, the multi-particle construct is able …
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Computational Investigation of Protein-Membrane Systems Involved in Cellular Trafficking
… To overcome the barrier the membranes pose for cellular trafficking between the outside and the inside, or between different compartments of the cell, nature has evolved elaborate ways of transporting targets across the membranes, utilizing specially designed protein machines. In this thesis, …
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Regulation of the cGAS-STING Pathway: Non-Agonist Activation and Cellular Trafficking
… IFN signaling is dynamically regulated by STING trafficking from the ER to the Golgi then to the lysosome. Cofactors and cellular mechanisms that facilitate STING trafficking and signaling are incompletely understood. In the settings of cancer immunotherapy, STING agonists induce strong …
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Cellular Trafficking and Processing Pathways of the Alzheimer β/A4 Amyloid Precursor Protein
<p>Extracellular deposition of the β/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. β/A4 amyloid is derived from the integral membrane amyloid precursor protein (APP). Secreted truncated forms of APP found in blood plasma and cerebrospinal fluid …
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Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity
… of proNE was a multistage process including trafficking to the cell surface, endocytosis through coated vesicles and possibly lipid rafts, and possible conversion to mature NE in late endosomes. The inhibition of proNE’s activation into mature NE was accompanied by the accumulation of proNE, …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
… understanding of the mechanisms that mediate MSC trafficking to inflamed tissue. Here, we first introduce key concepts in MSC biology and cellular trafficking, and highlight the relevance of MSC trafficking. We also introduce key concepts in cellular trafficking, particularly the leukocyte homing …
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Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
… reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a novel immunoregulatory function. Data contained within this dissertation provides insight into the molecular mechanism of an …
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Directed evolution in human cells via adenoviral replication
… distinctive post-translational modifications, cellular trafficking, and highly regulated chromatin architecture can all derail the activity of BOIs evolved in simpler systems. Current approaches to directed evolution in metazoan cells rely on labor-intensive and time-consuming screening …
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Cotranslational Folding of CFTR
… in the cell is dictated by its biogenesis, cellular trafficking, regulated function, and destruction. Cystic fibrosis (CF) is the direct result of perturbations in these processes. Treatment of CF mandates the understanding of the molecular events leading to CFTR loss-of-function. The …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… by which CRIP1a regulates CB1R activity and trafficking have not yet been identified; therefore the focus of this dissertation is to examine the cellular effects of CRIP1a on CB1R function and cellular trafficking.
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FROM SERUM TO TISSUE: GALECTIN-BINDING GLYCOFORMS OF SERUM GLYCOPROTEINS AS FUNCTIONAL BIOMARKERS
… variety of roles. Our findings suggest a basic cellular mechanism– galectins use their unique fine specificities to bind and regulate the cellular trafficking of glycoproteins, which could lead to functional effects, such as targeting a glycoprotein to either side of a cell, changing the time it …
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Growth-factor-induced mitogenesis: Trafficking determinants of the cellular response
… and its receptor. However, the dynamics of the cellular trafficking of growth factors and their receptors can be an important determinant of the cellular response to growth factor stimulation. We have explored this hypothesis using the epidermal growth factor (EGF) receptor regulation of …
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Viral and cellular proteins involved in vaccinia virus egress
… two distinct infectious virion forms, Intracellular Mature Virions (IMVs) and Extracellular Enveloped Virions (EEVs). The host cell microtubule trafficking machinery is hijacked by the virus at three distinct positions of the viral life cycle. After virus entry, the virus cores are …
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Cellular Prion Protein (PrPC): Identification and Characterization of Novel Interacting Partners
The cellular prion protein (PrPC) is highly conserved throughout the evolution of mammals. (What does this sentence mean? What do you mean by ``conserved´´? This protein was higly conserved during the evolution of mammals [pantera et al. 2009; Jiayu et al.2009] and the gene tree deduced from the …
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Identification and characterization of novel autoregulatory mechanism controlling ataxia telangiectasis mutated gene expression, protein traffiking and function
… and E2F1 levels. Elucidation of the underlying trafficking mechanism of ATM during such autoregulation and in DDR also revealed a novel ATM sub-cellular trafficking mechanism which was dependent on its own kinase activity. This trafficking mechanism involved DNA damage induced Golgi to nuclear …
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Characterization of the glycosylation and signal peptide sequences within the vaccinia virus m2 protein and influence on ERK1/2 and NF-kB activation
… of the NF-κB transcription factor during cellular infection establishes an anti-viral state via upregulation of proinflammatory proteins. Wild-type vaccinia virus (VV) strains subvert the immune response by expressing proteins that interfere with nuclear translocation of NF-κB. In …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
… BKPyV by examining the effects of knocking out cellular genes thought to be involved in bypass of the Golgi apparatus on viral release, known as GORASP1 and GORASP2. It was observed that single CRISPR-mediated knockouts of each gene both lead to a reduction in viral release, with a stronger …
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Cellular interactions of the cytolethal distending toxins
… in molecular details. Utilizing host uptake and trafficking system, pathogenic effector proteins, called toxins, have exploited existing pathways as a mean to access intracellular targets and modulate host cellular functions. Among known targets in the human host, nucleus has been an infrequent, …