Regulation of Cell Migration by Integrin -Mediated Adhesion

The second project focused on identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. Interestingly, this cDNA was found to be a truncated form of RACK1 that has one of the putative PKC binding sites, but lacks C-terminal sequences required to bind integrin beta cytoplasmic tails, and the tyrosine kinase, Src. Characterization of this molecule has demonstrated that RACK1, through its interaction with Src, plays an important role in regulating cell adhesion, protrusion, and directional cell migration.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Microbiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Cox, Elisabeth Abbot

Contributors dc:contributor

• Anna Huttenlocher

• Biology, Cell

Language dc:language

eng

Identifier

(MiAaPQ)AAI3030423

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/86634