{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/86634"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/86634","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Regulation of Cell Migration by Integrin -Mediated Adhesion","abstract":"The second project focused on identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. Interestingly, this cDNA was found to be a truncated form of RACK1 that has one of the putative PKC binding sites, but lacks C-terminal sequences required to bind integrin beta cytoplasmic tails, and the tyrosine kinase, Src. Characterization of this molecule has demonstrated that RACK1, through its interaction with Src, plays an important role in regulating cell adhesion, protrusion, and directional cell migration.","abstract_html":"The second project focused on identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. Interestingly, this cDNA was found to be a truncated form of RACK1 that has one of the putative PKC binding sites, but lacks C-terminal sequences required to bind integrin beta cytoplasmic tails, and the tyrosine kinase, Src. Characterization of this molecule has demonstrated that RACK1, through its interaction with Src, plays an important role in regulating cell adhesion, protrusion, and directional cell migration.","abstract_has_math":false,"creators":["Cox, Elisabeth Abbot"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Microbiology","degree_department":null,"school":null,"contributors":["Anna Huttenlocher"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:17:04Z","date_published":"2015-09-28T15:17:04Z","updated_at":"2026-07-22T22:26:27Z","subjects":["Biology, Cell"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3030423"],"render_values":[{"text":"(MiAaPQ)AAI3030423","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/86634","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Anna Huttenlocher"]},{"key":"dc:creator","label":"Author","values":["Cox, Elisabeth Abbot"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:17:04Z","10000-01-01","2001"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Microbiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Cell"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/86634","(MiAaPQ)AAI3030423"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The second project focused on identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. 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The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. Interestingly, this cDNA was found to be a truncated form of RACK1 that has one of the putative PKC binding sites, but lacks C-terminal sequences required to bind integrin beta cytoplasmic tails, and the tyrosine kinase, Src. Characterization of this molecule has demonstrated that RACK1, through its interaction with Src, plays an important role in regulating cell adhesion, protrusion, and directional cell migration.","Made available in DSpace on 2015-09-28T15:17:04Z (GMT). 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