Regulation of Glycogenolysis in Anaerobic Skeletal Muscle

Functional compartmentation of anaerobic metabolism was demonstrated in intact tissue. Force-independent ATP utilization, primarily the Ca 2+ pump of the sarcoplasmic reticulum, preferentially uses ATP derived from glycogenolysis. ATP produced by creatine kinase is used mostly by force-dependent ATP consuming processes, primarily the actomyosin-ATPase. Although prior evidence of sub-cytosolic metabolic compartmentation exists, the majority of these studies are not in intact cells or tissues. The demonstration here of functional compartmentation of ATP production for specific ATPases shows that metabolism needs to be considered with this in mind.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics and Computational Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Hsu, Alexander Chong-Koang

Contributors dc:contributor

• Dawson, M. Joan

• Biology, Animal Physiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3044120

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/85423