The Mechanism of Chemoprotection by 1-Cyano-2-Hydroxy-3-Butene, a Natural Component of Cruciferous Vegetables

In a final study, CHB was found to mediate a monofunctional DNA-directed increase in GST subunit Ya$\sb2,$ Yc$\sb2$ and QR mRNA levels, without a concomitant increase in mRNA levels of CYP 1A. This suggests that, in the previous study, the protection afforded against aflatoxin-induced carcinogenesis was through a monofunctional increase in phase II enzymes, particularly, the GST subunit Yc$\sb2.$ (Abstract shortened by UMI.).

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Staack, Richard Frank

Contributors dc:contributor

• Jeffery, Elizabeth H.

• Health Sciences, Oncology

Language dc:language

eng

Identifier

(MiAaPQ)AAI9812780

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84976