Yeast Mutants That Require the GPI Biosynthetic Gene GPI1 for Growth

The isolation of t-s smp3, gaa1, and gpi2 strains using a synthetic lethality screen demonstrates that this is a valid approach to identify genes involved in GPI anchor biosynthesis. This suggests that many of the remaining S.L. mutants are also likely to harbor mutations in GPI and cell wall assembly. Strategies to identify the remaining non- t-s/S.L. mutations include complementation of other conditional growth phenotypes (e.g. CFW hypersensitivity) or the non-sectoring phenotype.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Taron, Barbara Westfall

Contributors dc:contributor

• Peter A.B.Orlean

• Biology, Molecular

Language dc:language

eng

Identifier

(MiAaPQ)AAI9990161

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84920