{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84920"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84920","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Yeast Mutants That Require the GPI Biosynthetic Gene GPI1 for Growth","abstract":"The isolation of t-s smp3, gaa1, and gpi2 strains using a synthetic lethality screen demonstrates that this is a valid approach to identify genes involved in GPI anchor biosynthesis. This suggests that many of the remaining S.L. mutants are also likely to harbor mutations in GPI and cell wall assembly. Strategies to identify the remaining non- t-s/S.L. mutations include complementation of other conditional growth phenotypes (e.g. CFW hypersensitivity) or the non-sectoring phenotype.","abstract_html":"The isolation of t-s smp3, gaa1, and gpi2 strains using a synthetic lethality screen demonstrates that this is a valid approach to identify genes involved in GPI anchor biosynthesis. This suggests that many of the remaining S.L. mutants are also likely to harbor mutations in GPI and cell wall assembly. Strategies to identify the remaining non- t-s/S.L. mutations include complementation of other conditional growth phenotypes (e.g. CFW hypersensitivity) or the non-sectoring phenotype.","abstract_has_math":false,"creators":["Taron, Barbara Westfall"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biochemistry","degree_department":null,"school":null,"contributors":["Peter A.B.Orlean"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:28:31Z","date_published":"2015-09-25T22:28:31Z","updated_at":"2026-07-22T22:26:24Z","subjects":["Biology, Molecular"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9990161"],"render_values":[{"text":"(MiAaPQ)AAI9990161","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84920","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Peter A.B.Orlean"]},{"key":"dc:creator","label":"Author","values":["Taron, Barbara Westfall"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:28:31Z","10000-01-01","2000"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biochemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Molecular"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84920","(MiAaPQ)AAI9990161"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The isolation of t-s smp3, gaa1, and gpi2 strains using a synthetic lethality screen demonstrates that this is a valid approach to identify genes involved in GPI anchor biosynthesis. This suggests that many of the remaining S.L. mutants are also likely to harbor mutations in GPI and cell wall assembly. Strategies to identify the remaining non- t-s/S.L. mutations include complementation of other conditional growth phenotypes (e.g. CFW hypersensitivity) or the non-sectoring phenotype.","Made available in DSpace on 2015-09-25T22:28:31Z (GMT). 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This suggests that many of the remaining S.L. mutants are also likely to harbor mutations in GPI and cell wall assembly. Strategies to identify the remaining non- t-s/S.L. mutations include complementation of other conditional growth phenotypes (e.g. CFW hypersensitivity) or the non-sectoring phenotype.","Made available in DSpace on 2015-09-25T22:28:31Z (GMT). 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