University of Illinois at Urbana-Champaign
Chemotactic Sensory Transduction in Bacillus Subtilis: A New Enzyme and a New Pathway
Abstract
dc:descriptionChemotaxis towards substrates of the phosphoenolpyruvate-dependent-phosphotransferase system (PTS) in E. coli is accomplished using a chemoreceptor-independent signaling circuit in which phosphoryl flux through the PTS is monitored and used directly to modulate the activity of the chemotactic kinase. In contrast, chemotaxis towards PTS carbohydrates by B. subtilis requires the transmembrane chemoreceptor McpC; therefore, B. subtilis must employ a different sensory circuit to mediate such chemotaxis. The results in this study indicate that the sensory circuit mediating chemotaxis towards PTS carbohydrates utilizes the cytoplasmic methyl-accepting subdomain of McpC as a sensor for PTS stimuli. This receptor subdomain has not been reported to function as a sensor of chemical stimuli for any known chemoreceptor.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Biochemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Kristich, Christopher James
- Contributors dc:contributor
-
- Geroge W. Ordal
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3070359
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84787