Studies on Polysaccharide Synthesis and Solution Behavior

To better understand the interaction of water with hyaluronan, two uronic acids, beta-methyl glucuronic acid and beta-methyl galacturonic acid, were prepared, and their hydroxyl protons were studied using low temperature NMR. These results were compared to calculations of proton exchange in uronic acids. Calculations suggest that OH4 in glucuronic acid should exchange with solvent, whereas in galacturonic acid it should not. The NMR observations confirm the calculated predictions.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Flugge, Lisa Ann

Contributors dc:contributor

• Petillo, Peter A.

• Chemistry, Organic

Language dc:language

eng

Identifier

(MiAaPQ)AAI9989998

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84481