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University of Illinois at Urbana-Champaign
Mass Spectrometric Characterization of Peptides in Neurons
Abstract
dc:descriptionThe MALDI-based approach is inherently different from conventional methods, in that essentially all peptides present at significant concentrations are detected, not only those which are pre-selected or radioactively tagged. Furthermore, single cells, nerves, and vesicles are screened without the need to isolate each peptide from its complex cellular environment. Sampling, data acquisition, and strategies for the generation of molecular ion images are presented which reveal the utility of MALDI MS for direct and rapid neuropeptide characterization.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Garden, Rebecca Wells
- Contributors dc:contributor
-
- Sweedler, Jonathan V.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI9953020
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84454