Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach

Tetradentate oxorhenium(V) coordination motifs were subsequently investigated as possible modes by which the metal-chelate may be incorporated into a steroid-like structure. A novel amine amide thioether thiol (AATT) chelation paradigm was devised to replace the C and D rings of the steroid with a metal coordination sphere. A tetradentate oxorhenium(V) estradiol mimic was synthesized and exhibited much higher lipophilicity than the bis-bidentate DHT mimic, as well as sufficient stability to be assayed in vitro; however, it demonstrated low binding to the estrogen receptor.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Hom, Roy Kay

Contributors dc:contributor

• Katzenellenbogen, John A.

• Chemistry, Pharmaceutical

Language dc:language

eng

Identifier

(MiAaPQ)AAI9737132

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84365