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Showing 1 to 20 of 72 for “"Thioether"”.
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Investigation and application of substrate tolerant thioether forming enzymes
Thioether-containing compounds are involved in different biological functions in both prokaryotic and eukaryotic systems. Nature has evolved a treasure box of intriguing thioether containing natural products. Lanthipeptides contain thioether rings and have demonstrated diverse biological …
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Investigations of Thioether Generation for S-D-Ribosyl-L-homocysteine Synthesis
<p>Creation of the thioether linkage is a fundamental step for the chemical preparation of the bacterial quorum sensing molecule <em>S</em>-D-ribosyl-L-homocysteine (SRH). Although previous preparations of SRH and its analogues have been reported in the literature, they employ assorted methods with …
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Investigation of radical SAM-mediated thioether installation in RiPP natural products
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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COMPLEXES OF GROUP 10 METALS WITH NON-CLASSICAL AND THIOETHER-FUNCTIONALIZED N-HETEROCYCLIC CARBENE LIGANDS
… The forth part describes the synthesis of thioether-functionalized NHC precursors, and the coordination chemistry of these NHCs with platinum(II), palladium(II) and nickel(II), and the catalytic activities of these complexes. Additionally, the coordination chemistry of C,S,C-pincer ligands …
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The reaction of bis(thioether) complexes of (octaethylporphyrinato)ruthenium(II) with dioxygen, and the catalyzed O₂-oxidation of thioethers
… is proposed for the O₂-oxidation of the thioether ligands of Ru(OEP)(RR’S)₂ in acidic organic media. For example, for the bis(dms) system, in the "first stage", O₂ coordinates to Ru‶(OEP)(dms) formed by dissociation of a dms ligand. This is followed by electron transfer from the metal to …
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Synthesis, Molecular Structure and Reactivity of Di(1-cyclohepta-2,4,6-trienyl) thioether, S(C7H7)2 and Tri(1-cyclohepta-2,4,6-trienyl) amine, N(C7H7)3
… chemistry of di(1-cyclohepta-2,4,6-trienyl) thioether, S(C7H7)2 (1), tri(1-cyclohepta-2,4,6-trienyl) amine, N(C7H7)3 (24), and di(1-cyclohepta-2,4,6-trienyl) amine, NH(C7H7)2 (25). The reaction of tropylium bromide, C7H7Br, with the gas hydrogen sulfide (H2S) leads to the …
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Synthesis and Characterization of Hetero- and Homobimetallic Complexes of New Hard-Soft Binucleating Ligands
… ligands prepared in this work include phosphine, thioether and quinoline substituted (beta)-diketones along with the Schiff-base derivatives of the thioether (beta)-diketone. With these ligand systems, we can exploit the extensive transition metal coordination chemistry of (beta)-diketonates and …
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… activity and contain the characteristic thioether residues lanthionine (Lan) and methyllanthionine (MeLan). Installation of thioether crosslinks in lanthipeptide biosynthesis is carried out by designated synthetases and involves dehydration of Ser/Thr residues and cyclization via …
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The synthesis of novel organometallic materials.
… ligand, our target derivatives incorporate two thioether and two dithiolate environments as the overall chelating entity. The thioether functionalities are linked via suitable spacer groups and this feature should present a major advantage over traditional DMIT complexes, by adding solubility …
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Metal/polymer interactions in polyimide adhesives
… environments. This study examines the effect of thioether sulfur in the polyimide backbone on bond strength. X-ray photoelecton spectroscopy (XPS) and reflectance infrared spectroscopy indicated that certain metals catalyze the oxidation of the thioether sulfur. It was believed that this …
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Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach
… a steroid-like structure. A novel amine amide thioether thiol (AATT) chelation paradigm was devised to replace the C and D rings of the steroid with a metal coordination sphere. A tetradentate oxorhenium(V) estradiol mimic was synthesized and exhibited much higher lipophilicity than the …
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Mechanistic Studies of Lantibiotic Biosynthetic Enzymes and Discovery of Novel Lanthionine-Containing Peptides
… antimicrobial peptides containing unique thioether crosslinks, lanthionines and methyllanthionines. These motifs are introduced posttranslationally in a two-step process, which involves the dehydration of serines and threonines into dehydroalanines and dehydrobutyrines, respectively, and …
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Ruthenium-Thiozimtaldehyd-Komplexe
… Teil dieser Arbeit wird die Abspaltung der Thioether-Liganden vom Komplexfragment untersucht.
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New Rotaxane Ligands with Donors on Both the Axle and Wheel
… This was followed by the synthesis of a new thioether crown ether ligand and the resulting coordination of this ligand with the same metal centers studied with the model ligand. Where possible, the single crystal X-ray data for these coordination complexes was collected and has been …
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Chemical and chemoenzymatic syntheses of lantibiotics and other bioactive cyclic peptides
… is defined by the presence of the thioether-containing crosslinks lanthionine and methyllanthionine and includes many members with promising activities against clinically-relevant bacterial pathogens, including drug-resistant strains. These peptides are biosynthesized by translation …
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Mechanistic studies of lanthipeptide biosynthesis
… peptides with post-translationally incorporated thioether crosslinks named lanthionine. This family of natural products has garnered substantial attention during the past few decades due to their favorable biological activities and the potential for engineering. This thesis focuses on a subclass …
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A novel diazonium-sulfhydryl reaction in the inactivation of yeast alcohol dehydrogenase by diazotized 3-aminopyridine adenine dinucleotide
… which can then decompose to yield the thioether.
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Biosynthesis and engineering of lanthipeptides
… strains. These peptides are characterized by thioether crosslinks making them more resistant to degradation under physiological conditions. A detailed understanding of the biosynthesis and mode of action could allow engineering of these peptides for better pharmacological properties. In this …
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Entwicklung und Anwendung von Methoden zur Untersuchung der in vivo-Alkylierung in Abhängigkeit von der Tabakrauchexposition mit Hilfe unterschiedlicher Biomarker
… sollte neben den Mercaptursäuren auch die Thioether-Gesamtausscheidung bestimmt werden. Um das Gesamtbild abzurunden, ist allerdings auch die Erfassung von Addukten auf dem Level der DNA nötig. Diese Marker sollten möglichst mit genetischen Prädispositionen in Verbindung gebracht werden, …
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