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University of Illinois at Urbana-Champaign
Selective Targeting of RNA With Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops
Abstract
dc:descriptionHairpin loops occur in a region of RNA that doubles back on itself, leaving several unpaired bases at the terminus of a duplexed region. Dimers of 2-deoxystreptamine are known to bind to this class of secondary structure. Certain functionalized napthyridines are also known to display the appropriate donor-acceptor relationship to have a selective hydrogen bonding interaction with guanine. An effort was undertaken to combine these two disparate types of binding to enhance the overall selectivity of the ligand. The resulting compounds extended the methodology for binding to hairpin loops, and expanded the available repertoire for the chemistry of naphthyridines.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Meyer, Stephen Todd
- Contributors dc:contributor
-
- Hergenrother, Paul J.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3392218
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84347