Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"selective binding"”.
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Selective Targeting of RNA With Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops
… donor-acceptor relationship to have a selective hydrogen bonding interaction with guanine. An effort was undertaken to combine these two disparate types of binding to enhance the overall selectivity of the ligand. The resulting compounds extended the methodology for binding to hairpin …
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The mechanism of action of tumour necrosis factor-α / Jeffrey A.J. Barbara.
… side effects. Human TNF mutants with selective binding to the Human TNF receptors were employed to examine the role of these receptors in the mediation of TNF's cytotoxic and proinflammatory activities.
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Mechanism underlying linkage-selective polyubiquitin recognition
… to the myriad of polyUb signalling are Ub-binding domains (UBDs). Some UBDs can differentiate between types of polyUb chains and thus, are essential for the specificity of Ub signalling, but these mechanisms of linkage-selective polyUb recognition are less known. The work presented in my …
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Significance of active site residues in the n-domain selectivity of angiotensin-converting enzyme
… in substrate processing and inhibitor binding abilities. This suggests that active site residues differing between the two domains could provide unique interactions within the N-domain that allow for N-selective binding and processing. Literature reports of ACE crystal structures and …
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Synthesis and characterization of ring-opening metathesis polymers with pendant carborane groups
… dicarbollide or carborane anions demonstrated selective binding of cesium over sodium. Copolymerization and cross-linking were used to reduce the hydrophilicity and solubility of the materials in a stripping solution of strong (8M) nitric acid.
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Exploration of Small Peptide Binding Interactions with Inorganic Surfaces Across Timescales
Peptide adhesion presents a novel method of binding surfaces which could not otherwise be permanently bound through conventional methods. Two such surfaces of practical interest are titanium dioxide (the surface of osseous implants) and hydroxyapatite (the primary mineral component of bone). The …
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Surface Modification of Spherical Particles with Bioactive Glycopolymers
… polymers and a series of lectins revealed a selective binding towards the lectin wheat germ agglutinin (WGA) whereby the binding affinity of the protein to the polymer brushes was found to be magnitudes higher than to acetylglucosamine unimers. Lectin precipitation experiments revealed that 1 …
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Real time PCR measurement by fluorescence anisotropy
… Intercalating dye methods suffer from a lack of binding specificity, while probe methods are expensive and require increased assay optimization. In this thesis, a new method is presented for monitoring real-time PCR that utilizes the fluorescent anisotropy (FA) of labeled primers. FA, when …
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Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… interactions, recombinant reagents capable of selective binding (via SH2 domains) to phosphorylated receptors were generated. Overall results showed relatively unaffected VEGF activity in the presence of insulin; however, this relationship is likely altered within the diabetic state.
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Real-time Image Processing on an FPGA for an Intraoperative Goggle Device
… is removed from the patient’s body, except where binding between the dye and tumor cells has occurred. This selective binding between ICG and cancerous tissue allows for easy and accurate detection of cancer margins as well as detection of metastasis throughout the patient’s body. In order to …
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A Non-Biological Inhibition Based Sensing Technique (NIBS) for the Detection of Halogenated Disinfection By-Products in Water
… catalyst. The NIBS chemistry is focused on the selective binding of colorimetric reactions. Although colorimetric methods are selective to certain classes of compounds, they are not particularly sensitive. NIBS allows for both selective and sensitive detection of catalyst inhibition, without the …
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A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins
… identify PI 3-kinase-responsive proteins that is selective particularly for these. The approach features a unique three-tier affinity approach and incorporates a primary recruitment of target proteins to membranes of intact cells, selectively enriched in PtdIns(3,4)P2. In addition, this screen …
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Modeling and Spray Pyrolysis Processing of Mixed Metal Oxide Nano-Composite Gas Sensor Films
… substance with the sensor material through selective binding, adsorption and permeation of analyte. This research focuses on development and verification of a comprehensive mathematical model of mixed metal oxide thin film growth using spray pyrolysis technique (SPT). An experimental setup …
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Colloidal Self-Assembly: Particle Synthesis, Functionalisation and Applications
… control of their surface potentials. Due to its selective binding properties and thermal reversibility, deoxyribonucleic acid (DNA) was used to coat spherical polymeric colloids and subsequently have them assemble into high density colloidal gels. The formation and morphology of one- and …
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Shedding Light On General Anesthesia: Uncovering The Molecular Mechanisms For Propofol And Volatile Anesthetics
… further applied to determine the anesthetic binding sites within a vital protein target, synaptic GABAA receptors. The molecular recognition elements for propofol-protein interactions were probed using a novel hydrogen-bond null derivative. It was determined that the propofol 1-hydroxyl is …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… quinquestriatus scorpion venom, has shown selective binding to GBM cells, making it a promising candidate for diagnostic applications and improving tumor visualization. However, the molecular targets of Ctx are unclear, with Matrix Metalloproteinase-2 (MMP-2) and Neuropilin-1 (NRP-1) being …
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Detection of Biologically Important Molecules
… of anion sensors has been of great interest. The selective detection of a specific anion is particularly challenging. In the first chapter, I describe the synthesis of a TBS-protected fluorescein dye (1.1) and its use for the selective detection of fluoride. Solutions of 1.1 either in DCM or in …
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Point-of-care immunoassay system using carbon nanotube labels
… were demonstrated based on antibody and antigen binding. The lateral flow system was used for immobilization of capture molecules and passive sample transport by capillary action. CNTs conjugated to antibodies formed conductive network at the capture zone providing a visual indication …
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Investigating Protein Properties via Microfluidic Techniques
… with calmodulin are calculated. Finally, the selective binding between calmodulin and different types of aquaporins is investigated based on their relative binding affinities.
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Computational Modeling of Rna-Small Molecule and Rna-Protein Interactions
… this pipeline, we have successfully identified a selective compound binding to GA:UU motif. Both NMR and the subsequent MD simulation proved its selective binding to GA:UU motif flanked by two tandem flexible base pairs next to GA. Consistent to the 3D model, SAR analysis revealed that any …
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