Exploring the Structural and Functional Characteristics of a Catalytic DNA

Finally, the use of DNAzymes in biosensing applications was studied for Pb2+ detection. The molecular beacon DNAzyme biosensor was shown to be capable of detecting Pb2+ in soft to moderately hard water sources when used in conjunction with a handheld fluorometer. Detection limits under these conditions were lower than 72 nM, which is the EPA standard for Pb2+ in drinking water. An electrochemical Pb2+ sensor has also been developed by conjugating a ferrocene moiety to a gold electrode immobilized DNAzyme system.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Kim, Hee-Kyung

Contributors dc:contributor

• Lu, Yi

• Chemistry, Biochemistry

Language dc:language

eng

Identifier

(MiAaPQ)AAI3301162

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84286