Small Molecule Rhenium Carbonyl Complexes: Model Integrated-Design Technetium Estrogen Receptor Ligands for Tumor Imaging

It has been shown that inclusion of an acyl substituent on the cyclopentadiene ring lowers the pKa of the ring hydrogens sufficiently for labeling in an aqueous buffer. A divergent synthetic route to a pair of acyl-substituted cyclopentadienyl complexes, along with their alkyl analogs, has been developed. A modification of the cyclopentadienyl motif introduces a hydroxyl-substituted 2-pyridinylmethyl group onto the central ring. The inclusion of the pyridine moiety allows for displacement of one CO as the ligand wraps around the rhenium. The low electrophilicity of a beta-aryl-substituted-cyclopentenone has thus far been a complicating factor in the completion of these syntheses.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Ackroyd, Nathan C.

Contributors dc:contributor

• Katzenellenbogen, John A.

• Health Sciences, Radiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3290163

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84269