Small Molecule Rhenium Carbonyl Complexes: Model Integrated-Design Technetium Estrogen Receptor Ligands for Tumor Imaging
type: CreativeWork
description: It has been shown that inclusion of an acyl substituent on the cyclopentadiene ring lowers the pKa of the ring hydrogens sufficiently for labeling in an aqueous buffer. A divergent synthetic route to a pair of acyl-substituted cyclopentadienyl complexes, along with their alkyl analogs, has been developed. A modification of the cyclopentadienyl motif introduces a hydroxyl-substituted 2-pyridinylmethyl group onto the central ring. The inclusion of the pyridine moiety allows for displacement of one CO as the ligand wraps around the rhenium. The low electrophilicity of a beta-aryl-substituted-cyclopentenone has thus far been a complicating factor in the completion of these syntheses.
abstract: It has been shown that inclusion of an acyl substituent on the cyclopentadiene ring lowers the pKa of the ring hydrogens sufficiently for labeling in an aqueous buffer. A divergent synthetic route to a pair of acyl-substituted cyclopentadienyl complexes, along with their alkyl analogs, has been developed. A modification of the cyclopentadienyl motif introduces a hydroxyl-substituted 2-pyridinylmethyl group onto the central ring. The inclusion of the pyridine moiety allows for displacement of one CO as the ligand wraps around the rhenium. The low electrophilicity of a beta-aryl-substituted-cyclopentenone has thus far been a complicating factor in the completion of these syntheses.
author: Ackroyd, Nathan C.
language: eng
keywords: Health Sciences, Radiology
date published: 2015-09-25T22:13:44Z
date modified: 2026-07-22T22:26:22Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/84269