Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals

In addition to our non-steroidal work, we have designed and synthesized some high affinity steroidal compounds to probe the mechanism of androgen delivery to the cellular AR transcription mechanism. Sex hormone binding globulin (SHBG) binds testosterone, the principal circulating androgen, in high affinity and is believed to be directly involved in delivery of the hormone to cytoplasmic AR. Other high-affinity AR compounds, such as nor-testosterone, do not bind SHBG and their potential as imaging agents is not clear. We have prepared two classes of high affinity AR, 18F-labeled steroidal compounds, one of which also binds with high affinity to SHBG. In addition, we have studied their distribution in rat models in hope to elucidate the role that SHBG plays in radiopharmaceutical delivery.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Parent, Ephraim Edward

Contributors dc:contributor

• Katzenellenbogen, John A.

• Health Sciences, Radiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3223685

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84230