Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"rat models"”.
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Vascular action of glycine in hypertensive rat models
… aspartate (NMDA) receptor. Oral administration of glycine is helpful in the management of schizophrenia. While long-term oral treatment with glycine is considered to exert a cardio-vascular protective role by overcoming endothelial dysfunction and oxidative stress, there are no systematic …
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Gender-linked brain injury as exemplified in rat models of hypoxia and ischemia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigation of somatomotor-sympathetic brain circuit abnormalities in two rat models featuring inborn differences in emotional behavior
… efferents that play a role in integrating somatomotor and sympathetic functions. Several nodes of this circuitry, including the hypothalamic paraventricular nucleus (PVN), locus coeruleus (LC), and periaqueductal gray (PAG), are implicated in responses to stressful and emotionally …
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Healing of Bone Fracture in Type 1 Diabetic Rat Models: a Potential Gene Therapy Using Bone Morphogenetic Protein
… healing by applying gene therapy to a diabetic rat model.<br/><br/><b>Stages & objectives</b>: 1) Build a closed femoral transverse fracture rat model and investigate the role of BMP-6 in normal fracture healing. A self-designed guillotine system was employed to induce transverse fracture. …
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The role of substance P in cerebral edema associated with rat and human infarction and contusion
… A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes …
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Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
… addition, we have studied their distribution in rat models in hope to elucidate the role that SHBG plays in radiopharmaceutical delivery.
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Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia
… to gene expression. * Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model. * Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as …
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Development of New Regeneration Methods in Animal Models with Chronic Tympanic membrane Perforations Using Tissue Engineering Techniques
Tympanic Membrane (TM) perforation, in particular chronic otitis media, is one of the most frequent clinical problems in the otolaryngology field, which sometimes presents conductive healing loss. This study consists of three purposes and experiments; 1) we developed new animal models for chronic …
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Overcoming skin rejection in composite tissue allotransplantation
… consequences and mechanism of skin rejection in rat models. These studies indicate that in the event of allograft failure, there is minimal damage to the vascular pedicle of a composite tissue allotransplant, even after full rejection, making retransplantation possible. Furthermore, there is only …
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An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue
… Previously, a 100% toxoplasmosis infection rate was found in 72 lung biopsy samples acquired from patients. This compared with 10% in healthy controls. Little is known of immune mechanisms acting on T. gondii infected lung tissue. Research on rat and mouse models found an association between …
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New virulence mechanisms in Yersinia pestis, the plague (Black Death)-causing bacterium: A re-emerging and bioterror pathogen
… aerosolization of Y. pestis in two animal models. First, we characterized Y. pestis strains lacking murein, or Braun, lipoprotein (Lpp), an outer membrane protein conserved within the Enterobacteriaceae family. We then cured wild-type and ∆lpp mutant strains of virulent Y. pestis CO92 …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated pregnant rats; hypoxic-ischemic encephalopathy (HIE) in 10-day-old rat pups. In the first part of our study, we demonstrated that nicotine exposure induces aberrant brain development in P10 …
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Development of water-insoluble chitosan patch scaffold for regeneration of tympanic membranes
Tympanic membrane (TM) perforation is a common problem in otology. Perforated TM can be managed with an appliance of paper patch, myringoplasty, or tympanoplasty. A paper patch is not biocompatible having low flexibility and the other operations need aseptic surgical environment. A novel …
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INDIVIDUAL DIFFERENCES IN IMPULSIVE ACTION AND TEMPORAL ESTIMATION: INTERACTION WITH THE SEROTONIN (5-HT) 5-HT2A RECEPTOR
… and/or delay-averse behavior with poor consideration of negative consequences. An important temporal aspect of this construct underlies impulsive behaviors, and high impulsive individuals display differences in cognitive timing abilities (e.g., temporal overestimation). The neurobiological and …
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Acetate Increases Brain Purine Metabolism And Glial Cell Culture Fatty Acid Content: Studies Investigating Glyceryl Triacetate's Therapeutic Mechanism Of Action
… is anti-inflammatory and neuroprotective in rat models of neuroinflammation and Lyme neuroborreliosis. Oral administration of glyceryl triacetate (GTA) is used to induce acetate supplementation in rodents, which increases plasma acetate and brain acetyl-CoA levels. Acetyl-CoA is a ubiquitous …
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Novel Delivery Systems For Iron Replenishment
… Ferric Pyrophosphate (FPP), which was demonstrated to be very stable and safe for parenteral administration. Passive delivery of FPP was not successful due to its high molecular weight (745 Da) and low lipid solubility. Transdermal delivery of FPP using chemical permeation enhancers, …
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Aspects of sepsis/SIRS - An experimental study on fluid therapy, vitamin C and plasma volume in increased permeability
… and potentially harmful tissue oedema. Restoration of plasma volume with intravenous fluids is a cornerstone in the treatment of SIRS, but the infused fluids would be expected to leak through the capillary membrane to a greater extent, being less effective and further aggravating oedema Thus, …
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Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… Therefore proper cardiac development is imperative in optimizing cardiac function throughout life. A key process in determining</p> <p>cardiomyocyte endowment, and thus cardiac function, is the period of terminal differentiation. This involves the maturation of cardiomyocytes and is essential …
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