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University of Illinois at Urbana-Champaign
Mechanistic Studies and Synthetic Applications of Phosphite Dehydrogenase
Abstract
dc:descriptionCytochrome c oxidase, an enzyme that catalyzes the reduction of oxygen to water, has a binuclear center as well as a unique post-translational modification in the active site. Specifically, there is a crosslink between the nitrogen (Nepsilon2) of His240 and the carbon (Cepsilon 2) of Tyr244 (numbers correspond to CcO from bovine heart). The significance of the linkage was investigated by comparing the physicochemical properties of a model compound, 2-(imidazolyl-1-yl-4-methylphenol) to p-cresol.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Vrtis, Jennifer Marie
- Contributors dc:contributor
-
- van der Donk, Wilfred A.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3070466
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84091