Synthesis and Reactivity of Electroactive Carbon Sulfide Ligands and Studies on Modifications of Nucleic Acids

Finally, a separate study into the selective selenization of nucleic acid oligonucleotides was pursued. By using the soluble Se-transfer agent (i-PrC5H4)2TiSe5 in a new method with solid-phase phosphoramidite oligonucleotide synthesis, a mono-, di-, tri-, and tridecanucleotide of DNA with one phosphoroselenoate modification as well as a dinucleotide of RNA modified with one phosphoroselenoate were synthesized. The utility of phosphate backbone modifications in nucleic acid chemistry has been pursued for phosphorothioates and may now be studied for selenium analogues.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Holloway, Geoffrey Alan

Contributors dc:contributor

• Rauchfuss, Thomas B.

• Chemistry, Inorganic

Language dc:language

eng

Identifier

(MiAaPQ)AAI3023076

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84040