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The utility of phosphate backbone modifications in nucleic acid chemistry has been pursued for phosphorothioates and may now be studied for selenium analogues.","abstract_html":"Finally, a separate study into the selective selenization of nucleic acid oligonucleotides was pursued. By using the soluble Se-transfer agent (i-PrC5H4)2TiSe5 in a new method with solid-phase phosphoramidite oligonucleotide synthesis, a mono-, di-, tri-, and tridecanucleotide of DNA with one phosphoroselenoate modification as well as a dinucleotide of RNA modified with one phosphoroselenoate were synthesized. 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