Micromachined Sensors and Their Applications in the Study of Mechanical Response of Single Living Cells

Both the one- and two-component force sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neurons. The major findings of the studies include: The force response of monkey kidney fibroblasts is strongly linear, reversible and repeatable under large deformations, with a small stiffening at the initial deformation stage; Actin filaments play a dominant role in taking the cellular internal forces; Mechanical indentation/compression may induce actin agglomeration inside the cell, which supplies a perfect example of cellular mechanotransduction; The in vivo stretch force response of Drosophila axons is linear, and there is a rest tension in the axons and they maintain this rest tension; Tension in the axons is required for normal synaptic function, and muscle twitches may be involved in tuning this tension.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Mechanical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Yang, Shengyuan

Contributors dc:contributor

• Saif, M. Taher A.

• Biophysics, General

Language dc:language

eng

Identifier

(MiAaPQ)AAI3290440

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/83893