{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/83893"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/83893","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Micromachined Sensors and Their Applications in the Study of Mechanical Response of Single Living Cells","abstract":"Both the one- and two-component force sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neurons. The major findings of the studies include: The force response of monkey kidney fibroblasts is strongly linear, reversible and repeatable under large deformations, with a small stiffening at the initial deformation stage; Actin filaments play a dominant role in taking the cellular internal forces; Mechanical indentation/compression may induce actin agglomeration inside the cell, which supplies a perfect example of cellular mechanotransduction; The in vivo stretch force response of Drosophila axons is linear, and there is a rest tension in the axons and they maintain this rest tension; Tension in the axons is required for normal synaptic function, and muscle twitches may be involved in tuning this tension.","abstract_html":"Both the one- and two-component force sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neurons. The major findings of the studies include: The force response of monkey kidney fibroblasts is strongly linear, reversible and repeatable under large deformations, with a small stiffening at the initial deformation stage; Actin filaments play a dominant role in taking the cellular internal forces; Mechanical indentation/compression may induce actin agglomeration inside the cell, which supplies a perfect example of cellular mechanotransduction; The in vivo stretch force response of Drosophila axons is linear, and there is a rest tension in the axons and they maintain this rest tension; Tension in the axons is required for normal synaptic function, and muscle twitches may be involved in tuning this tension.","abstract_has_math":false,"creators":["Yang, Shengyuan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":["Saif, M. 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