Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes

The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Deszo, Eric Louis

Contributors dc:contributor

• Freund, Gregory G.

• Health Sciences, Pathology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3086046

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/83551